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phosphoinositide-3-Kinase Adaptor Protein 1 Proteins (PIK3AP1)

Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Additionally we are shipping PIK3AP1 Antibodies (86) and PIK3AP1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIK3AP1 118788 Q6ZUJ8
PIK3AP1 83490 Q9EQ32
PIK3AP1 294048  
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Top PIK3AP1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PIK3AP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) Interaction Partners

Human phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) interaction partners

  1. Abi-1 (show ABI1 Proteins) promotes Abl (show ABL1 Proteins)-mediated BCAP (show PHF11 Proteins) phosphorylation and suggest that Abi-1 (show ABI1 Proteins) in general coordinates kinase-substrate interactions

Mouse (Murine) phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) interaction partners

  1. Nck (show NCK1 Proteins)-mediated recruitment of BCAP to the BCR (show BCR Proteins) regulates the PI(3 (show PI3 Proteins))K-Akt (show AKT1 Proteins) pathway in B cells.

  2. BCAP is an essential activator of the PI3K pathway downstream of TLR signaling.

  3. BCAP is a unique TIR domain-containing toll (show TLR4 Proteins) like receptor (TLR) signaling adapter crucial for linking TLRs to PI3K activation and regulating the inflammatory response.

  4. As macrophages engage their pathogenic targets, innate immune receptors trigger increased expression of BCAP, which endows them with the capacity to withstand further challenges from ongoing cellular insults, such as endoplasmic reticulum stress.

  5. BCAP-(L) (but not BCAP-(S)) is a negative regulator of the TLR-mediated host defense system in macrophages.

  6. BCAP and CD19 have complementary roles in BCR-mediated phosphoinositide 3-kinase activation

  7. model in which blunting of BCAP-mediated activation signaling in developing NK cells promotes functionality, terminal maturation, and long-term survival

PIK3AP1 Protein Profile

Protein Summary

Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation (By similarity). May be involved in the survival of mature B-cells via activation of REL (By similarity).

Gene names and symbols associated with PIK3AP1

  • phosphoinositide-3-kinase adaptor protein 1 (PIK3AP1)
  • phosphoinositide-3-kinase adaptor protein 1 (Pik3ap1)
  • 1810044J04Rik protein
  • BCAP protein
  • RP11-34E5.3 protein

Protein level used designations for PIK3AP1

B cell adaptor protein , B-cell adapter for phosphoinositide 3-kinase , B-cell phosphoinositide 3-kinase adapter protein 1 , phosphoinositide 3-kinase adapter protein 1 , B cell phosphoinositide 3-kinase adaptor

GENE ID SPECIES
118788 Homo sapiens
83490 Mus musculus
294048 Rattus norvegicus
608653 Canis lupus familiaris
374268 Gallus gallus
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