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PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Additionally we are shipping PEA15 Antibodies (103) and PEA15 Kits (8) and many more products for this protein.
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High PED expression is associated with esophageal carcinoma.
The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.
Latent HCMV infection of CD34 (show CD34 Proteins) + cells protects cells from FAS (show FAS Proteins)-mediated apoptosis through the cellular IL-10 (show IL10 Proteins)/PEA-15 pathway.
New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.
PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
Omi/HtrA2 (show HTRA2 Proteins) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (show HTRA2 Proteins) pro-apoptotic marker in the various hepatocellular carcinoma cell lines
Results suggest that neurochemical adaptations of brain FADD (show FADD Proteins), as well as its interaction with PEA-15, could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression
Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) influences dephosphorylation of epidermal growth factor receptor (EGFR (show EGFR Proteins)) via extracellular signal-regulated kinases ERK1/2 sequestration in the cytoplasm.
Tumor suppressor PEA15 is a regulator of genome integrity and is an integral component of the DNA damage response pathway.
Up-regulated chaperone-mediated autophagy activity characteristic of most types of cancer cell enhances oncogenesis by shifting the balance of PED function toward tumor promotion.
Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.
Activated astrocytes are known to clear the Abeta (show APP Proteins) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (show PPARG Proteins)) represses transcription of the ped/pea-15 gene.
The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.
PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (show PPP1R11 Proteins)-methyladenine rescued TGF-beta1 (show TGFB1 Proteins) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (show TGFB1 Proteins) effects in muscle.
Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2.
we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (show MAPK1 Proteins) pathways under gonadotropin releasing hormone stimulation
PEA-15 regulates T-cell proliferation
PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
phosphoprotein enriched in astrocytes 15
, Astrocytic phosphoprotein PEA-15
, 15 kDa phosphoprotein enriched in astrocytes
, Phosphoprotein enriched in astrocytes, 15kD
, astrocytic phosphoprotein PEA-15
, homolog of mouse MAT-1 oncogene
, phosphoprotein enriched in diabetes
, phosphoprotein enriched in astrocytes 15A
, mammary transforming gene 1