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phosphoprotein Enriched in Astrocytes 15 Proteins (PEA15)

PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Additionally we are shipping PEA15 Antibodies (104) and PEA15 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PEA15 8682 Q15121
Rat PEA15 PEA15 364052 Q5U318
PEA15 18611 Q62048
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Top PEA15 Proteins at antibodies-online.com

Showing 7 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$680.36
Details
HOST_Wheat germ Human GST tag 25 μg Log in to see 9 Days
$591.43
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 5 Days
$385.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

PEA15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for phosphoprotein Enriched in Astrocytes 15 (PEA15) Interaction Partners

Human phosphoprotein Enriched in Astrocytes 15 (PEA15) interaction partners

  1. High PED expression is associated with esophageal carcinoma.

  2. The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.

  3. Latent HCMV infection of CD34 (show CD34 Proteins) + cells protects cells from FAS (show FAS Proteins)-mediated apoptosis through the cellular IL-10 (show IL10 Proteins)/PEA-15 pathway.

  4. New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.

  5. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  6. Omi/HtrA2 (show HTRA2 Proteins) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (show HTRA2 Proteins) pro-apoptotic marker in the various hepatocellular carcinoma cell lines

  7. Results suggest that neurochemical adaptations of brain FADD (show FADD Proteins), as well as its interaction with PEA-15, could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression

  8. Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) influences dephosphorylation of epidermal growth factor receptor (EGFR (show EGFR Proteins)) via extracellular signal-regulated kinases ERK1/2 sequestration in the cytoplasm.

  9. Tumor suppressor PEA15 is a regulator of genome integrity and is an integral component of the DNA damage response pathway.

  10. Up-regulated chaperone-mediated autophagy activity characteristic of most types of cancer cell enhances oncogenesis by shifting the balance of PED function toward tumor promotion.

Mouse (Murine) phosphoprotein Enriched in Astrocytes 15 (PEA15) interaction partners

  1. Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.

  2. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  3. Activated astrocytes are known to clear the Abeta (show APP Proteins) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).

  4. Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (show PPARG Proteins)) represses transcription of the ped/pea-15 gene.

  5. The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.

  6. PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (show PPP1R11 Proteins)-methyladenine rescued TGF-beta1 (show TGFB1 Proteins) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (show TGFB1 Proteins) effects in muscle.

  7. Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2.

  8. we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (show MAPK1 Proteins) pathways under gonadotropin releasing hormone stimulation

  9. PEA-15 regulates T-cell proliferation

  10. PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.

PEA15 Protein Profile

Protein Summary

This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Gene names and symbols associated with PEA15

  • phosphoprotein enriched in astrocytes 15 (PEA15)
  • phosphoprotein enriched in astrocytes 15 (pea15)
  • Astrocytic phosphoprotein PEA-15 (pea15)
  • phosphoprotein enriched in astrocytes 15 (Pea15)
  • phosphoprotein enriched in astrocytes 15A (Pea15a)
  • DKFZp459O1410 protein
  • HMAT1 protein
  • HUMMAT1H protein
  • Mat1 protein
  • MAT1H protein
  • PEA-15 protein
  • Pea15 protein
  • Pea15a protein
  • PED protein
  • Pkcs15 protein

Protein level used designations for PEA15

phosphoprotein enriched in astrocytes 15 , Astrocytic phosphoprotein PEA-15 , 15 kDa phosphoprotein enriched in astrocytes , Phosphoprotein enriched in astrocytes, 15kD , astrocytic phosphoprotein PEA-15 , homolog of mouse MAT-1 oncogene , phosphoprotein enriched in diabetes , phosphoprotein enriched in astrocytes 15A , mammary transforming gene 1

GENE ID SPECIES
677706 Macaca mulatta
705026 Macaca mulatta
100145359 Xenopus (Silurana) tropicalis
100152480 Sus scrofa
100174153 Pongo abelii
100286636 Salmo salar
8682 Homo sapiens
364052 Rattus norvegicus
734852 Xenopus laevis
510586 Bos taurus
610113 Canis lupus familiaris
18611 Mus musculus
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