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phosphoribosyl Pyrophosphate Synthetase 1 Proteins (PRPS1)

PRPS1 encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Additionally we are shipping PRPS1 Antibodies (13) and PRPS1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRPS1 5631 P60891
PRPS1 19139 Q9D7G0
PRPS1 29562 P60892
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Top PRPS1 Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$325.50
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,849.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,849.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,849.00
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$2,524.50
Details

PRPS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced PRPS1 Proteins

  1. Human PRPS1 Protein expressed in Escherichia coli (E. coli) - ABIN666934 : Li, Lu, Peng, Ding: Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site. in The Biochemical journal 2006 (PubMed)
    Show all 2 references for ABIN666934

More Proteins for phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) Interaction Partners

Human phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) interaction partners

  1. evaluation of current literature on PRPS1-related syndromes and summaries of potential therapies [review]

  2. analysis of intrafamilial phenotypic variation associated with a single PRPS1 mutation in syndromic or nonsyndromic hearing impairment

  3. CRC (show CALR Proteins) cells that overexpressed miR124 or with knockdown of RPIA (show RPIA Proteins) or PRPS1 had reduced DNA synthesis and proliferation, whereas cells incubated with an inhibitor of miR124 had significantly increased DNA synthesis and proliferation and formed more colonies.

  4. Study identified the critical region in the ARTS promoter and demonstrated that the Sp1 transcription factor (show SP1 Proteins) could regulate the activity of the ARTS promoter through multiple Sp1 (show PSG1 Proteins) binding sites.

  5. Females with a missense mutation in PRPS1, exhibit neuropathy, hearing loss and retinopathy.

  6. the de novo purine synthesis inhibitor lometrexol effectively abrogated PRPS1 mutant-driven drug resistance.

  7. The expression of different genes encoding subunits of PRPS (show MSMB Proteins) enzyme is affected by hypoxia in tumor glioma cells, but the effect of hypoxia is modified by suppression of endoplasmic reticulum stress signaling enzyme ERN1 (show ERN1 Proteins).

  8. respective phenotypic presentation seems to be determined by the exact PRPS1 mutation and the residual enzyme activity, the latter being largely influenced by the degree of skewed X-inactivation

  9. The crystal structure of the ADP-binding pocket of the PRPS1 D52H-mutant and evidence of reduced inhibitor sensitivity.

  10. Review: discuss role of PRPS1 mutations in hearing loss.

Mouse (Murine) phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) interaction partners

  1. Only unedited pri-miR (show MLXIP Proteins)-376 RNAs were detected in the cochlea suggesting that the activity of PRPS1 in the inner ear may not be regulated through the editing of miR (show MLXIP Proteins)-376 cluster.

  2. PRPS1 loss of function mutations cause a type of nonsyndromic X-linked sensorineural deafness, DFN2

PRPS1 Protein Profile

Protein Summary

This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PRPS1

  • phosphoribosyl pyrophosphate synthetase 1 (PRPS1)
  • phosphoribosyl pyrophosphate synthetase 1 (Prps1)
  • ribose-phosphate pyrophosphokinase I -like (LOC314140)
  • 2310010D17Rik protein
  • ARTS protein
  • C76571 protein
  • C76678 protein
  • CMTX5 protein
  • DFN2 protein
  • DFNX1 protein
  • PPRibP protein
  • Prps-1 protein
  • PRS-I protein
  • PRSI protein

Protein level used designations for PRPS1

dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1) , deafness 2, perceptive, congenital , deafness, X-linked 2, perceptive, congenital , phosphoribosyl pyrophosphate synthase I , ribose-phosphate diphosphokinase 1 , ribose-phosphate pyrophosphokinase 1 , phosphoribosyl pyrophosphate synthetase I , PRS-I

GENE ID SPECIES
5631 Homo sapiens
19139 Mus musculus
29562 Rattus norvegicus
781227 Bos taurus
314140 Rattus norvegicus
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