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serine Hydroxymethyltransferase 1 (Soluble) Proteins (SHMT1)

SHMT1 encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. Additionally we are shipping serine Hydroxymethyltransferase 1 (Soluble) Antibodies (56) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SHMT1 SHMT1 287379  
SHMT1 6470 P34896
SHMT1 20425 P50431
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Top serine Hydroxymethyltransferase 1 (Soluble) Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Encephalitozoon cuniculi His tag   1 mg Log in to see 56 to 66 Days
$3,294.50
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$3,366.00
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,366.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,366.00
Details
HOST_Human Human His tag   10 μg Log in to see 5 Days
$203.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details

SHMT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced serine Hydroxymethyltransferase 1 (Soluble) Proteins

  1. Human SHMT1 Protein expressed in Escherichia coli (E. coli) - ABIN667617 : Herbig, Chiang, Lee, Hills, Shane, Stover: Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN667617

More Proteins for serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) Interaction Partners

Human serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

  1. an association between MTRR (show MTRR Proteins) 66 and SHMT1 1420 polymorphisms and spaceflight-induced vision changes

  2. our meta-analysis suggested that the SHMT1 C1420T polymorphism was associated with decreased risk of breast cancer.

  3. SHMT1 knockdown in lung cancer cells leads to cell cycle arrest and to p53 (show TP53 Proteins)-dependent apoptosis.

  4. In this meta-analysis, SHMT1 C1420T polymorphism did not have a significant association with the risk of cancer overall.

  5. SHMT1 exists in solution as a tetramer, both in the absence and presence of PLP (show PLP1 Proteins), while SHMT2 (show SHMT2 Proteins) undergoes a dimer-to-tetramer transition.

  6. found evidence for association of SHMT1 C1420T polymorphism with significantly reduced risk of breast cancer in Asians

  7. SHMT1 C1420T polymorphism is not associated with overall cancer development.

  8. serine hydroxymethyltransfarase C1420T reduces risk for both acute lymphoblastic leukemia and acute myeloid leukemia (show BCL11A Proteins) and influences disease progression in acute lymphoblastic leukemia

  9. SHMT1 C1420T and DNMT3B (show DNMT3B Proteins) C46359T polymorphisms are not associated with HNC (show MMP8 Proteins) development in Brazilian population, however, SHMT1 C1420T polymorphism is less frequent in patients with primary site of tumor in larynx

  10. geography-specific effects of the SHMT1 polymorphism that render Europeans susceptible to colorectal caner, but not Americans.

Mouse (Murine) serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

  1. Shmt1 and dietary folate deficiency influence metabolic markers of homocysteine remethylation in mice.

  2. SHMT1 and TYMS (show TYMS Proteins) localization to the nucleus is essential to prevent uracil accumulation in DNA

  3. Data show that Shmt1 hemizygosity was associated with increased risk for intestinal cancer in Apc (show APC Proteins)(min)(/+) mice through a gene-by-diet interaction.

  4. These results provide evidence that disruption of Shmt1 expression causes NTDs by impairing thymidylate biosynthesis and shows that changes in the expression of genes that encode folate-dependent enzymes may be key determinates of NTD risk.

  5. Shmt1 (SHMT1), but not Srr (show SRR Proteins), is likely to be one of the genetic components regulating prepulse inhibition in mice and possibly relevant to human schizophrenia.

  6. mitochondrial SHMT-derived one-carbon units are essential for folate-mediated one-carbon metabolism in the cytoplasm

  7. SHMT1 and SHMT2 (show SHMT2 Proteins) are functionally redundant in nuclear de novo thymidylate biosynthesis

Rabbit serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

  1. we have expressed, characterized, and determined the crystal structures of rabbit cytosolic serine hydroxymethyltransferase T254A and T254C mutant forms, in the absence and presence of substrates.

Arabidopsis thaliana serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) interaction partners

  1. SHM1 and SHM2 operate in a redundant manner in one-carbon metabolism of nonphotorespiring cells with a high demand of one-carbon units.

  2. The senescence is initiated in shm1-1 under photorespiratory conditions. Transcription of the senescence marker SAG12 is enhanced in shm1-1.

  3. Structural modeling of SHM1, SHM2, and SHM4 presented features that may explain the activity differences between the mitochondrial and cytosolic isozymes.

  4. The characterization and expression of SHMT1 in A. thaliana. [SHMT1]

  5. SHM1 expression is required for mitochondrial serine hydroxymethyltransferase (show SHMT2 Proteins) activity and proper function of the C2 cycle during growth in ambient air.

  6. SHMT1 interacts with GLU1 and this interaction is necessary for photorespiratory serine hydroxymethyltransferase (SHMT) activity.

serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) Protein Profile

Protein Summary

This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.

Gene names and symbols associated with SHMT1

  • serine hydroxymethyltransferase 1 (soluble) (Shmt1)
  • serine hydroxymethyltransferase 1 (soluble) (shmt1)
  • serine hydroxymethyltransferase 1 (soluble) (SHMT1)
  • serine transhydroxymethyltransferase 1 (SHM1)
  • AI324848 protein
  • AI385541 protein
  • C81125 protein
  • CSHMT protein
  • F20D10.50 protein
  • F20D10_50 protein
  • LRRGT00032 protein
  • MEL-32 protein
  • MGC53442 protein
  • mshmt protein
  • mshmt1 protein
  • mshmt2 protein
  • SERINE HYDROXYMETHYLTRANSFERASE 1 protein
  • SERINE TRANSHYDROXYMETHYLASE protein
  • SERINE TRANSHYDROXYMETHYLTRANSFERASE protein
  • serine transhydroxymethyltransferase 1 protein
  • SHMT protein
  • Shmt1 protein
  • SHMT2 protein
  • STM protein
  • zgc:66171 protein
  • zgc:77524 protein

Protein level used designations for SHMT1

serine hydroxymethyltransferase, cytosolic , serine hydroxymethyltransferase 1 (soluble) , zSHMT-1 , SHMT , glycine hydroxymethyltransferase , serine methylase , cytoplasmic serine hydroxymethyltransferase , cytosolic serine hydroxymethyltransferase , serine hydroxymethyl transferase , serine hydroxymethyltransferase 2 (mitochondrial)

GENE ID SPECIES
287379 Rattus norvegicus
380048 Xenopus laevis
394021 Danio rerio
416520 Gallus gallus
454490 Pan troglodytes
489536 Canis lupus familiaris
548668 Xenopus (Silurana) tropicalis
100117303 Nasonia vitripennis
100159628 Acyrthosiphon pisum
100171460 Pongo abelii
100600675 Nomascus leucogenys
6470 Homo sapiens
20425 Mus musculus
100009405 Oryctolagus cuniculus
443544 Ovis aries
509002 Bos taurus
829949 Arabidopsis thaliana
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