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serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) ELISA Kits

SPTLC2 encodes a long chain base subunit of serine palmitoyltransferase. Additionally we are shipping serine Palmitoyltransferase, Long Chain Base Subunit 2 Antibodies (73) and serine Palmitoyltransferase, Long Chain Base Subunit 2 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SPTLC2 630537  
Anti-Rat SPTLC2 SPTLC2 300272  
Anti-Human SPTLC2 SPTLC2 9517 O15270
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Top serine Palmitoyltransferase, Long Chain Base Subunit 2 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Mouse 0.055 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$757.89
Details

More ELISA Kits for serine Palmitoyltransferase, Long Chain Base Subunit 2 Interaction Partners

Mouse (Murine) serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) interaction partners

  1. The expression of SPT2 was stronger in vascular smooth muscle cells and neointima of carotid arteries from knock-out mice compared to wild-type.

  2. Data suggest that overexpression of serine palmitoyltransferase (Sptlc1 (show SPTLC1 ELISA Kits) and Sptlc2, serine palmitoyltransferase long chain base subunit 1 (show SPTLC1 ELISA Kits)/2) to elevate de novo sphingolipid biosynthesis induces autophagy in the liver.

  3. SPTLC2 knockout mice showed decreased ceramide levels in the epidermis, which impaired water-holding capacity and barrier function.

  4. Ldlr (show LDLR ELISA Kits) gene knockout mice with myeloid cell-specific Sptlc2 haploinsufficiency exhibited significantly less atherosclerosis than controls.

  5. Data show that LCAT (show LCAT ELISA Kits) activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2)+/- and sphingomyelin synthase 2 (Sms2 (show SGMS2 ELISA Kits))-/- mice, but markedly lower in ApoE (show APOE ELISA Kits)-/- and Ldlr (show LDLR ELISA Kits)-/- mice.

  6. results suggest that Sptlc2-mediated de novo ceramide synthesis is an essential source of C18:0 and very long chain, but not of shorter chain, ceramides in the heart

  7. Inflammatory response elicited by lipopolysaccharide increases serine palmitoyltransferase activity via upregulation of Sptlc2 in macrophages.

  8. Deficiency of Sptlc2 induces necrotic lesions in gastrointestinal cells followed by atrophic change of the tissue in short term.

  9. Both Sptlc1 (show SPTLC1 ELISA Kits) and Sptlc2 interactions are necessary for Serine palmitoyl-CoA transferase (SPT (show AGXT ELISA Kits)) activity in vivo and SPT (show AGXT ELISA Kits) activity directly influences plasma sphingolipid levels

  10. The expression and activities of SPT (show AGXT ELISA Kits) in mouse liver increased significantly following fumonisin B1 treatment.

Human serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) interaction partners

  1. The activities of the hLCB2a mutants were measured in the presence of ssSPTa (show SPTSSA ELISA Kits) and ssSPTb (show SPTSSB ELISA Kits) and was found that all decrease enzyme activity.

  2. Mutations in SPTLC2 are associated with increased deoxySL formation causing hereditary sensory and autonomic neuropathy type 1 (HSANI) in a familial study.

  3. Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.

  4. results suggest that SPTLC2 mutations are not a common cause for genetic sensory neuropathies.

  5. Results suggest that functional serine palmitoyltransferase is not a dimer, but a higher organized complex, composed of three distinct subunits (SPTLC1 (show SPTLC1 ELISA Kits), SPTLC2 and SPTLC3 (show SPTLC3 ELISA Kits)) with a molecular mass of 480 kDa.

  6. discovery of 2 proteins, ssSPTa (show SPTSSA ELISA Kits) and ssSPTb (show SPTSSB ELISA Kits), which each interacts with both hLCB1 (show SPTLC1 ELISA Kits) and hLCB2, suggesting that there are 4 distinct human SPT (show AGXT ELISA Kits) isozymes.

serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Antigen Profile

Antigen Summary

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.

Gene names and symbols associated with SPTLC2

  • serine palmitoyltransferase, long chain base subunit 2 (SPTLC2) antibody
  • serine palmitoyltransferase, long chain base subunit 2 (sptlc2) antibody
  • demilune cell and parotid protein 2 (Dcpp2) antibody
  • salivary protein 2 (Spt2) antibody
  • serine palmitoyltransferase LCB2 subunit (LOC100689415) antibody
  • serine palmitoyltransferase, long chain base subunit 2 (Sptlc2) antibody
  • serine palmitoyltransferase, long chain base subunit 2a (sptlc2a) antibody
  • AI173915 antibody
  • Dcpp-2 antibody
  • EG630537 antibody
  • hLCB2a antibody
  • HSN1C antibody
  • LCB2 antibody
  • LCB2A antibody
  • mKIAA0526 antibody
  • NSAN1C antibody
  • Pomt2 antibody
  • SPT-2 antibody
  • SPT2 antibody
  • sptlc2 antibody
  • zgc:110661 antibody

Protein level used designations for SPTLC2

serine palmitoyltransferase, long chain base subunit 2 , serine palmitoyltransferase 2-like , sublingual parotid tongue-2 salivary protein , LCB 2 , Long chain base biosynthesis protein 2 , Long chain base biosynthesis protein 2a , SPT 2 , Serine-palmitoyl-CoA transferase 2 , serine palmitoyltransferase 2 , long chain base biosynthesis protein 2a , serine palmitoyltransferase, subunit II , serine-palmitoyl-CoA transferase 2 , LCB2a , long chain base biosynthesis protein 2 , protein-O-mannosyltransferase 2

GENE ID SPECIES
100059392 Equus caballus
100446763 Pongo abelii
100464437 Ailuropoda melanoleuca
100566142 Anolis carolinensis
100601824 Nomascus leucogenys
630537 Mus musculus
300272 Rattus norvegicus
100689415 Cricetulus griseus
9517 Homo sapiens
20773 Mus musculus
100158010 Sus scrofa
101115373 Ovis aries
366697 Rattus norvegicus
444190 Xenopus laevis
423379 Gallus gallus
480403 Canis lupus familiaris
537972 Bos taurus
553646 Danio rerio
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