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The protein encoded by SPINT1 is a member of the Kunitz family of serine protease inhibitors. Additionally we are shipping serine Peptidase Inhibitor, Kunitz Type 1 Proteins (8) and serine Peptidase Inhibitor, Kunitz Type 1 Kits (4) and many more products for this protein.
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Human Polyclonal SPINT1 Primary Antibody for EIA, WB - ABIN954931
Chen, Wang, Chou, Chen, Rorke, Chen, Chai, Eckert, Johnson, Lin: Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. in The Journal of biological chemistry 2010
Show all 3 references for ABIN954931
The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase (show ST14 Antibodies) levels than downregulation of HAI1. Matriptase (show ST14 Antibodies) may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis.
The findings suggest that the oncogenic activity of hepsin (show HPN Antibodies) arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF (show HGF Antibodies)/MET signalling and epithelial cohesion
HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2 (show F2RL1 Antibodies)-dependent p38 mitogen-activated protein kinase (show MAPK14 Antibodies) signaling.
the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyte growth factor activator inhibitor Type I (HAI-1 or SPINT-1), an upstream inhibitor of the c-MET signaling pathway.
Data suggest HAI1 exhibits structural features consistent with classification in MANEC subclass of PAN (show SUPT6H Antibodies)/apple domain family with unifying features such as two additional disulfide bonds, two extended loop regions, and additional alpha-helical elements.
Matriptase (show ST14 Antibodies) activity was suppressed by the expression of HAI-1.
The results of the present study identified HAI-1 as a favorable prognostic marker for prostate cancer and may indicate that HAI-1 could be a therapeutic target for the treatment of this malignancy.
HAI-1 expression correlates with the differentiation status of colorectal epithelia and could serve as a differentiation marker.
HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign
Crystal structures of matriptase (show ST14 Antibodies) in complex with its inhibitor hepatocyte growth factor activator inhibitor-1
By completing our structural characterization of the previously unknown N-terminal region of HAI-1, we provide new insight into the interplay between tertiary structure and the inhibitory activity of a multidomain protease inhibitor
HAI-1 regulates the activity of activated matriptase (show ST14 Antibodies), whereas HAI-2 (show SPINT2 Antibodies) has an essential role in regulating prostasin (show PRSS8 Antibodies)-dependent matriptase (show ST14 Antibodies) zymogen activation.
HAI-1/SPINT1 has a crucial role in suppressing intestinal tumorigenesis, which implies a novel link between epithelial cell surface (show EPCAM Antibodies) serine protease (show F2 Antibodies) inhibitors and protection from carcinogenic stimuli.
mutations in Prss8 (show PRSS8 Antibodies) restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (show SPINT2 Antibodies)-deficient embryos.
HAI-1 has a crucial suppressive role in oral squamous cell carcinoma cells' invasiveness.
HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation.
HAI-1/SPINT1 plays an important role in maintaining colonic epithelium integrity.
HAI-1 is required for branching morphogenesis in the chorioallantoic placenta.
The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms.
serine peptidase inhibitor, Kunitz type 1
, kunitz-type protease inhibitor 1
, kunitz-type protease inhibitor 1-like
, hepatocyte growth factor activator inhibitor type 1
, serine protease inhibitor, Kunitz type 1
, hepatocyte growth factor activator inhibitor 1
, hepatocyte growth factor activator inhibitor-1