SPINT1 antibody (AA 451-529)

Catalog No. ABIN669861

Product Details anti-SPINT1 Antibody

Target: SPINT1 (serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1))

Binding Specificity: AA 451-529

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPINT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HAI-1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SPINT1

Target: SPINT1 (serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1))

Alternative Name: HAI-1 (SPINT1 Products)

Synonyms: HAI-1 antibody, HAI antibody, HAI1 antibody, MANSC2 antibody, cb376 antibody, sb:cb376 antibody, spint1l antibody, zgc:64075 antibody, serine peptidase inhibitor, Kunitz type 1 antibody, serine protease inhibitor, Kunitz type 1 antibody, serine peptidase inhibitor, Kunitz type 1 b antibody, serine peptidase inhibitor, Kunitz type 1 a antibody, SPINT1 antibody, Spint1 antibody, spint1b antibody, spint1a antibody

Background:

Synonyms: Hepatocyte Growth Factor Activator Inhibitor 1, Spint1, Hai1, HGFA Inhibitor 1, HAI-1, SPIT1_HUMAN.

Background: HGFA Inhibitor 1 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 1 also inhibits trypsin, and MTSP-1 (Matriptase), a serine proteinase that also activates HGF. HGFB Inhibitor 1 is a splice variant of HGFA Inhibitor 1, and contains a 16 amino acid insert after the first kringle domain, relative to the HGFA Inhibitor 1 sequence.

Gene ID: 6692