serine/arginine-Rich Splicing Factor 2 (SRSF2) ELISA Kits

The protein encoded by SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Additionally we are shipping SRSF2 Antibodies (34) and SRSF2 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SRSF2 6427 Q01130
SRSF2 20382 Q62093
SRSF2 494445 Q6PDU1
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.054 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 13 to 16 Days
  96 Tests Log in to see 15 to 18 Days
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More ELISA Kits for SRSF2 Interaction Partners

Human serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. Data suggest that RBM25 is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 = RNA binding motif protein 25; SRSF2 = serine- and arginine-rich splicing factor 2 (show SRSF1 ELISA Kits))

  2. mutations in the SRSF2/ASXL1 (show ASXL1 ELISA Kits)/RUNX1 (show RUNX1 ELISA Kits) gene panel identified as significant prognostic markers in systemic mastocytosis

  3. It was found that the absence of mutations in the SRSF2, ASXL1 (show ASXL1 ELISA Kits), and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

  4. These findings provide insight into the functions of SRSF2 in HSV-1 replication and gene expression.

  5. SRSF2 mutations were identified in Chinese AML (show RUNX1 ELISA Kits) patients. Patients with SRSF2 mutations were older than those with wild-type. No differences in the sex, blood parameters, FAB (show FANCB ELISA Kits) subtypes, and karyotypes were seen between AML (show RUNX1 ELISA Kits) patients with and without SRSF2 mutations. SRSF2 mutation was not an independent prognostic factor in AML (show RUNX1 ELISA Kits) patients.

  6. The genotype frequencies of SRSF2 SNP rs237057 were CT 7.6% and TT 92.4% in Childhood AML (show RUNX1 ELISA Kits) patients.

  7. NSrp70 (show NSRP1 ELISA Kits) acts as a new molecular counterpart for alternative splicing of target RNA, counteracting SRSF1 (show SRSF1 ELISA Kits) and SRSF2 splicing activity.

  8. We present experimental evidence that splicing factor (show SLU7 ELISA Kits) SRSF1 (show SRSF1 ELISA Kits), SRSF2, U2AF35 (show U2AF1 ELISA Kits), U2AF65 (show U2AF59 ELISA Kits) and KHSRP (show KHSRP ELISA Kits) expression levels in gastrointestinal tract (colon, gastric and pancreatic) tumors differ compare to healthy tissues and in cell lines.

  9. Data show that tet methylcytosine dioxygenase 2 TET2 (show TET2 ELISA Kits), isocitrate dehydrogenases 1/2 IDH1 (show IDH1 ELISA Kits)/IDH2 (show IDH2 ELISA Kits), serine/arginine-rich splicing factor 2 SRSF2, splicing factor 3b subunit 1 SF3B1 (show SF3B1 ELISA Kits), and ras proteins (KRAS/NRAS) are not conserved in dog mast Cell tumors.

  10. Depletion of two of the most potent inhibitors of SMP2 (show LPIN3 ELISA Kits) exon 7 inclusion, SRSF2 or SRSF3 (show SRSF3 ELISA Kits), in cell lines derived from SMA (show SMN1 ELISA Kits) patients, increased SMN2 (show SMN1 ELISA Kits) exon 7 inclusion and SMN (show STMN1 ELISA Kits) protein level.

Mouse (Murine) serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. Mice expressing Srsf2 mutation Srsf2P95H, which commonly occurs in individuals with MDS (show MECOM ELISA Kits) and AML (show RUNX1 ELISA Kits), in an inducible, hemizygous manner in hematopoietic cells rapidly succumbed to fatal bone marrow failure, demonstrating that Srsf2-mutated cells depend on the wild-type Srsf2 allele for survival.

  2. Findings have shown that SRSF2 not only is involved in splicing regulation of a large number of transcripts but also activates transcription of metabolism-related genes and transcription factors.

  3. Depletion of SRSF2 enhances reovirus replication and cytopathic effect, suggesting that T1L mu2 (show AP2M1 ELISA Kits) modulation of splicing benefits the virus.

  4. HIV-1-Tat (show TAT ELISA Kits) Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A (show DYRK1A ELISA Kits) Kinase.

  5. The findings suggest that intact SRSF2 is essential for the functional integrity of the hematopoietic system and that its mutations likely contribute to development of myelodysplastic syndromes.

  6. SRSF2 mutations alter SRSF2's normal sequence-specific RNA binding activity, thereby altering the recognition of specific exonic splicing enhancer motifs to drive recurrent mis (show AMH ELISA Kits)-splicing of key hematopoietic regulators

  7. Study reports that SRSF2 (also known as SC35, an SR-splicing factor (show SLU7 ELISA Kits)) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release.

  8. Specific effects on regulated splicing by SR proteins SRSF1 (show SRSF1 ELISA Kits) and SRSF2 depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.

  9. Deficiency of the splicing factor (show SLU7 ELISA Kits) Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn (show STMN1 ELISA Kits) splicing.

  10. Oct-4 distribution was examined relative to that of the unphosphorylated form of RNA polymerase II (Pol II) and splicing factor (SC 35) in the intranuclear entities such as perichromatin fibrils.

SRSF2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.

Gene names and symbols associated with SRSF2

  • serine/arginine-rich splicing factor 2 (SRSF2) antibody
  • serine/arginine-rich splicing factor 2 (Srsf2) antibody
  • serine/arginine-rich splicing factor 2 (srsf2) antibody
  • D11Wsu175e antibody
  • MRF-1 antibody
  • pr264 antibody
  • sc-35 antibody
  • sc35 antibody
  • sfrs2 antibody
  • sfrs2a antibody
  • Sfrs10 antibody
  • srp30b antibody

Protein level used designations for SRSF2

SR splicing factor 2 , splicing component, 35 kDa , splicing factor SC35 , splicing factor, arginine/serine-rich 2 , myelin regulatory factor 1 , putative myelin regulatory factor 1 , splicing factor Sc35 , splicing factor, arginine/serine-rich 2 (SC-35) , SC-35 , PR 264 protein , arginine/serine-rich2 splicing factor

6427 Homo sapiens
20382 Mus musculus
494445 Rattus norvegicus
508312 Bos taurus
396195 Gallus gallus
768117 Sus scrofa
380435 Xenopus laevis
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