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over-expression causes apoptosis-like cell death which is dependent on the kinase activity. Additionally we are shipping serine/threonine Kinase 17b Proteins (10) and serine/threonine Kinase 17b Kits (1) and many more products for this protein.
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Human Polyclonal STK17B Primary Antibody for IF, IHC (p) - ABIN1882073
Sanjo, Kawai, Akira: DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. in The Journal of biological chemistry 1998
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Human Polyclonal STK17B Primary Antibody for IF, IHC (p) - ABIN303291
Kawai, Matsumoto, Takeda, Sanjo, Akira: ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. in Molecular and cellular biology 1998
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Human Polyclonal STK17B Primary Antibody for EIA, WB - ABIN954980
Gatzka, Newton, Walsh: Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Human Polyclonal STK17B Primary Antibody for ELISA, WB - ABIN4306258
Friedrich, Cui, Hernandez, Weist, Andersen, Zhang, Huang, Walsh: Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. in The Journal of biological chemistry 2007
Human Polyclonal STK17B Primary Antibody for WB - ABIN252640
Friedrich, Wen, Bain, Kee, Katayama, Murre, Hedrick, Walsh: DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. in International immunology 2005
A significant interaction between variants in STK17B and PAX8 (show PAX8 Antibodies), in papillary thyroid cancer susceptibility, is reported.
ChIP assays showed that in U937 cells MYB (show MYB Antibodies) binds to a conserved element upstream of the DRAK2 transcription start site.
DRAK2 protein directly binds to the type I TGF-beta (show TGFB1 Antibodies) receptor and Knockdown of DRAK2 suppresses the tumorigenic ability of breast cancer cells.
DRAK2 and protein kinase D (show PRKD1 Antibodies) form a novel signaling module that controls calcium homeostasis following T cell activation.
DRAK2 kinase activity is regulated in a calcium-dependent manner and that Ser (show SIGLEC1 Antibodies)(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase
Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells.
Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 (show PTGS2 Antibodies) in colorectal cancer.
Data provide insight into the role of Drak2 in autoimmune diseases by showing that Drak2 may not suppress TGF-beta (show TGFB1 Antibodies) signaling in T cells, and therefore may contribute to autoimmune disease via other molecular pathways.
results demonstrate that DRAK2 plays an important role in primary and memory T cell responsiveness to allografts
T cells from Drak2(-/-) mice exhibited enhanced sensitivity to T cell receptor-mediated stimulation with a reduced requirement for costimulation
DRAK2 transduces non-apoptotic signals during thymocyte differentiation.
Drak2 expresses in the T cell compartment but is not T cell-specific; it plays critical roles in T cell apoptosis and memory T cell development
DRAK2 may be a novel target for stimulating protective immunity to viral pathogens
DRAK2 may have a role in regulating the GC reaction and the response to thymus-dependent antigens, and DRAK2-deficiency is not involved in regulating intrinsic B-cell apoptosis.
reduced viral load in the brains of Drak2(-/-) mice
over-expression causes apoptosis-like cell death which is dependent on the kinase activity
serine/threonine-protein kinase 17B
, serine/threonine kinase 17b (apoptosis-inducing)
, serine/threonine kinase 17b
, serine/threonine kinase 17B
, serine/threonine-protein kinase 17B-like
, DAP kinase-related apoptosis-inducing protein kinase 2
, death-associated protein kinase-related 2