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SGK2 encodes a serine/threonine protein kinase. Additionally we are shipping SGK2 Antibodies (81) and SGK2 Kits (11) and many more products for this protein.
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Loss of the paternally derived allele of the imprinted SGK2 gene is associated with Shwachman-Diamond syndrome.
These findings suggest that SGK2 promotes hepatocellular carcinoma progression and mediates glycogen synthase kinase 3 beta/beta-catenin (show CTNNB1 Proteins) signaling in hepatocellular carcinoma cells.
SGK2 stimulated hOAT4 (show SLC22A9 Proteins) transport activity by abrogating the inhibitory effect of Nedd4-2 (show NEDD4L Proteins) on the transporter.
Activation of hepatocyte pregnane X receptor (show NR1I2 Proteins) is mediated through serum- and glucocorticoid-regulated kinase (SGK)2.
Glucocorticoid inducible kinase isoforms SGK1 (show SGK1 Proteins)-3 are novel potent stimulators of Slc6a19 (show SLC6A19 Proteins) and may thus participate in the regulation of neutral amino acid transport in vivo.
Powerful stimulating effect of all three isoforms of SGK (show SGK1 Proteins) on K(+) channels. Those effects may participate in regulation of epithelial transport, cell proliferation, and neuromuscular excitability.
All three members of the SGK (show SGK1 Proteins) family of kinases SGK1 (show SGK1 Proteins)-3 and protein kinase B (show AKT1 Proteins) stimulate the slowly activating K(+) channel (show KCNC4 Proteins) KCNE1 (show KCNE1 Proteins)/KCNQ1 (show KCNQ1 Proteins). The kinases may thus participate in the regulation of KCNE1 (show KCNE1 Proteins)-dependent transport and excitability.
Co-expression of SGK1 (show SGK1 Proteins), but not of SGK2 or SGK3 (show SGK3 Proteins), increased Kv 4.3/KChIP2b (show KCNIP2 Proteins) channel currents.
the nucleotide substitution in the Sgkl gene is the causative mutation for defective hair growth in the ypc mutant mouse and the signaling pathway involving SGKL plays an essential role in mammalian hair development
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants.
serine/threonine-protein kinase Sgk2
, serum/glucocorticoid regulated kinase family, member 3
, serum/glucocorticoid regulated kinase 2
, serine/threonine-protein kinase Sgk3
, serum/glucocorticoid-regulated kinase 2