sigma Non-Opioid Intracellular Receptor 1 Proteins (SIGMAR1)

SIGMAR1 encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. Additionally we are shipping SIGMAR1 Antibodies (33) and SIGMAR1 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIGMAR1 10280 Q99720
SIGMAR1 18391 O55242
Rat SIGMAR1 SIGMAR1 29336 Q9R0C9
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Top SIGMAR1 Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,031.33
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,031.33
Details
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$2,042.33
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$2,042.33
Details

SIGMAR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,
,

More Proteins for sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) Interaction Partners

Human sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 and Orai1 channels was significantly correlated to a lower overall survival.

  2. Genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with Major Depressive Disorder and Bipolar Disorder.

  3. Data demonstrate the involvement of SIGMAR1 in motor neuron maintenance and survival by correlating mutations in this gene to distal motor dysfunction and highlight the chaperone activity of sigma-1R as a critical aspect in distal hereditary motor neuropathy pathology.

  4. Changes of Sig1R and SOD2 (show SOD2 Proteins) expression point to mitochondria as main organelle responsible for survival of tumor cells exposed to hypoxia or oxidative stress. Studied proteins are involved in intracellular response to stress related with different concentrations of oxygen.

  5. Collectively, these studies define Sig1R as a key mediator of TRAIL induction of cancer-specific killing.

  6. crystal structures of the human sigma1 receptor in complex with two chemically divergent ligands, PD144418 and 4-IBP (show TSPO Proteins)

  7. Expression of mutant Sig-1R protein reduces mitochondrial ATP production, inhibits proteasome activity and causes mitochondrial injury, aggravating ER stress-induced neuronal death.

  8. Removal of the S1R gene in the Superoxide Dismutase-1 (SOD-1 (show SOD1 Proteins)) mouse model of ALS (show IGFALS Proteins) exacerbated the neurodegenerative condition and resulted in a significantly reduced longevity.

  9. mutations of the SIGMAR1 gene worsen outcome in Alzheimer's disease and myotrophic lateral sclerosis supporting a role of Sig-1R in neurodegenerative disease.

  10. examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (show APOD Proteins) and SIGMAR1 genes to find possible associations with IS risk, IS severity and recovery after IS

Mouse (Murine) sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. Findings identified five alternatively spliced variants of the sigma1 receptor gene Sigmar1 using a polymerase chain reaction cloning approach.

  2. inhibition of Sig (show PICALM Proteins)-1 R prevented cocaine-induced TrkB (show NTRK2 Proteins) activation in hippocampal neurons.

  3. Activation of S1R, necessary for its effect on the BDNF (show BDNF Proteins) pathway, represents a core component of the mode of action of pridopidine. Since the newly identified pathways are downregulated in neurodegenerative diseases, including Huntington Disease (HD (show HTT Proteins)) , these findings suggest that pridopidine may exert neuroprotective effects beyond its role in alleviating some symptoms of HD.

  4. Findings demonstrate that spinal cord injury activates astrocyte sigma-1 receptors leading to increases in the expression of the gap junction protein, connexin 43 (show GJA1 Proteins) and astrocyte activation in the lumbar dorsal horn, and ultimately contribute to the induction of bilateral below-level mechanical allodynia.

  5. Study found: sigma-1 receptor is abundant in dorsal root ganglion (DRG) neuronal soma, but not in satellite cells; sigma-1 receptor is absent in processes of DRG neurons; in DRG neurons, S1R targets endoplasmic reticulum, nuclear envelope, and plasma membrane.

  6. The findings indicate that the activation of sigma1R can alleviate postpartum "depression" through increasing nNOS (show NOS1 Proteins)-NO-CREB (show CREB1 Proteins) activities.

  7. Sigma1R may be a novel retinal stress modulator, and targeting it even after disease onset may afford retinal neuroprotection.

  8. Study focused on sigma-1 receptor (Sig-1R), a chaperone at endoplasmic reticulum, and investigated its protective functions; results reveal that zinc finger protein 179 (show RNF112 Proteins) plays a novel role in neuroprotection.

  9. the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity

  10. Results suggest that Sig (show PICALM Proteins)-1Rs modulate ethanol drinking, locomotor stimulation and conditioned taste aversion, strengthening the notion that drugs acting on the Sig-1R system may have potential for treating alcohol-use disorders

Cow (Bovine) sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity

Guinea Pig sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. S1R has a GXXXG motif in its second transmembrane region, and these motifs are often involved in oligomerization of membrane proteins. Disrupting mutations within the GXXXG motif shifted the fraction of the higher oligomeric states toward smaller states.

SIGMAR1 Protein Profile

Protein Summary

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor\; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

Gene names and symbols associated with SIGMAR1

  • sigma non-opioid intracellular receptor 1 (SIGMAR1)
  • sigma non-opioid intracellular receptor 1 (Sigmar1)
  • sigma non-opioid intracellular receptor 1 (LOC100341228)
  • sigma non-opioid intracellular receptor 1 (sigmar1)
  • sigma non-opioid intracellular receptor 1-like (LOC100521392)
  • AL024364 protein
  • ALS16 protein
  • mSigmaR1 protein
  • oprs1 protein
  • SIG-1R protein
  • Sigma1R protein
  • SR-BP protein
  • SR-BP1 protein
  • SRBP protein
  • zgc:56378 protein

Protein level used designations for SIGMAR1

SR31747 binding protein 1 , aging-associated gene 8 protein , hSigmaR1 , sigma 1-type opioid receptor , opioid receptor, sigma 1 , sigma1-receptor , sigma1R , Sigma 1-type opioid receptor , Sigma1-receptor , sigma1-receptor (sterol-isomerase like protein) , sterol isomerase-like protein

GENE ID SPECIES
10280 Homo sapiens
18391 Mus musculus
29336 Rattus norvegicus
481587 Canis lupus familiaris
538903 Bos taurus
100859748 Gallus gallus
100135589 Cavia porcellus
100341228 Oryctolagus cuniculus
101116710 Ovis aries
446848 Xenopus laevis
393952 Danio rerio
100521392 Sus scrofa
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