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anti-Human BDKRB2 Antibodies:
anti-Rat (Rattus) BDKRB2 Antibodies:
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Human Monoclonal BDKRB2 Primary Antibody for IF, IP - ABIN967979
Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation. in The Journal of biological chemistry 2002
Show all 5 Pubmed References
Human Monoclonal BDKRB2 Primary Antibody for IF, IP - ABIN967978
Xie, Browning, Hay, Mackman, Ye: Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt. in The Journal of biological chemistry 2000
Show all 5 Pubmed References
The most characteristic signaling pathways for B2R and D2R (show DRD2 Antibodies), dependent on intracellular Ca(2 (show CA2 Antibodies)+) and cAMP concentration, respectively, were analyzed in cells presenting similar endogenous expression of B2R and D2R.The evidence of B2R-D2R (show DRD2 Antibodies) dimerization may open new perspectives in the modulation of diverse cellular functions which depend on their activation.
These results indicate that KOR (show OPRK1 Antibodies) can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB (show CREB1 Antibodies) signaling pathway, leading to a significant increase in cell proliferation.
Study demonstrated the ability of long-chain polyunsaturated fatty acids to act as agonist to the B2R at nanomolar concentrations and to induce receptor conformational changes.
Data suggest that N-myc (and STAT) interactor (NMI (show NMI Antibodies)) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1 (show MAPK3 Antibodies)/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC (show FAM126A Antibodies)).
Data show that mRNA and protein of bradykinin type 2 receptors, but not bradykinin type 1 receptors, were abundant in cultured c-Kit (show KIT Antibodies)+ progenitor cells.
BDKRB2 +9/-9 bp polymorphisms affected the gene expression and nitric oxide production, which were associated with radiographic severity of osteoarthritis, suggesting that the BDKRB2 +9/ -9 bp polymorphisms may act as a genetic modulator of osteoarthritis, and play an essential role in inflammatory process in osteoarthritis.
authors found significant interactions among PRKCA (show PKCa Antibodies), NOS3 (show NANOS3 Antibodies) and BDKRB2 genotypes associated with enalapril responses.
Bronchial B2R expression is constitutively elevated in allergic asthma and is further increased after allergen exposure together with NF-kB expression.
Report the presence of nuclear B2R in the utero-placental unit and reduced abundance of nuclear B2R in extravillous trophoblast in preeclampsia.
Data provide evidence that the BDKRB2 +9/-9 polymorphisms influence pro-inflammatory cytokine levels in knee osteoarthritis by altering TLR-2 (show TLR2 Antibodies) expression.
B2R signaling promotes aortic rupture within a ApoE (show APOE Antibodies)-eficient mouse model associated with the ability to stimulate inflammatory phenotypes of neutrophils and vascular smooth muscle cells.
B2R activation occurs in the diabetic skin and delays wound healing. B2R blockade improves skin wound healing in diabetic mice and is a potential therapeutic approach to diabetic ulcers.
a novel pathway by which C5aR (show C5AR1 Antibodies)/B2R cross-talk couples transendothelial leakage of plasma proteins to the cytokine circuitry that coordinates antiparasite immunity.
investigated if expression of B1 and B2 kinin receptors can be affected by IL-4 (show IL4 Antibodies) and IL-13 (show IL13 Antibodies); data show, for the first time, that IL-4 (show IL4 Antibodies) and IL-13 (show IL13 Antibodies) decrease kinin receptors in a STAT6 (show STAT6 Antibodies)-dependent mechanism
Data suggest that nicotine impairs mucosa-dependent Bdkrb2 (bradykinin B2 receptor) mediated trachea relaxation; nicotine also down-regulates tracheal expression of COX2/Ptgs2 (cyclooxygenase 2 (show PTGS2 Antibodies)) and mPGES-1 (show PTGES Antibodies) (microsomal prostaglandin E2 synthase-1).
Data suggest that expression of Bdkrb2 is up-regulated in adrenal medulla as the result of immobilization stress; data from CRH (corticotropin-releasing hormone (show CRH Antibodies)) knockout mice suggest this up-regulation requires catecholaminergic glucocorticoids.
B1R (show BDKRB1 Antibodies) and B2R receptors exert a critical role in the establishment of persistent hypersensitivity observed in an experimental autoimmune encephalomyelitis model
Data indicate that Bdkrb2(-/-) mice have elevated plasma angiotensin-(1-7) and messenger RNA and protein for its receptor Mas (show MAS1 Antibodies).
Null mutations at the p66 (show POLD3 Antibodies) and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney in mice.
These findings suggest that activation of the bradykinin/B2R pathway contributes to development of host resistance to visceral leishmaniasis.
A persistent B2R-beta2AR (show ADRB2 Antibodies) heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR (show ADRB2 Antibodies) enhanced beta2AR (show ADRB2 Antibodies)-mediated release of tPA (show PLAT Antibodies).
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.
B2 bradykinin receptor
, BK-2 receptor
, bradykinin B2 receptor
, ornithokinin receptor
, bradykinin receptor B2
, B2 bradykinin receptor-like
, b2 bradykinin receptor-like
, bradykinin receptor, beta 2
, kinin B2