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anti-Human MAS1 Antibodies:
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Human Polyclonal MAS1 Primary Antibody for ICC, IF - ABIN270653
Bosnyak, Widdop, Denton, Jones: Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats. in International journal of hypertension 2011
Show all 3 Pubmed References
Human Polyclonal MAS1 Primary Antibody for ICC, IF - ABIN4332754
da Silveira, Coelho, Vieira, Sachs, Barroso, Costa, Bretas, Bader, de Sousa, da Silva, dos Santos, Simões e Silva, Teixeira: Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, MAS, in experimental models of arthritis. in Journal of immunology (Baltimore, Md. : 1950) 2010
Show all 3 Pubmed References
Human Polyclonal MAS1 Primary Antibody for IHC, IHC (p) - ABIN4892714
Wang, Liang, Leung: The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos. in PLoS ONE 2015
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
Here, we review the role and effects of ACE2 (show ACE2 Antibodies), ACE2 (show ACE2 Antibodies) activators, Ang-(1 (show ANGPT1 Antibodies)-7) and synthetic Mas receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE (show ACE Antibodies)-Ang II (show AGT Antibodies)-AT1 (show AGTR1 Antibodies) axis.
Downregulation of ACE2 (show ACE2 Antibodies)/Ang-(1 (show ANGPT1 Antibodies)-7)/Mas axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (show PAK1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/Snail1 (show SNAI1 Antibodies) pathways.
These results indicated that angiotensin-(1-7)/ACE2/Mas axis may reduce liver lipid accumulation partly by regulating lipid-metabolizing genes through ATP/P2 receptor/CaM signaling pathway.
Ang-(1 (show ANGPT1 Antibodies)-7) downregulated AT1R (show AGTR1 Antibodies) mRNA, upregulated mRNA levels of Ang II (show AGT Antibodies) type 2 receptor (AT2R (show AGTR2 Antibodies)) and Mas receptor (MasR) and p38-MAPK (show MAPK14 Antibodies) phosphorylation and suppressed H22 cell-endothelial cell communication
MAS1 might act as an inhibitory regulator of breast cancer.
Data show that MAS receptor exhibited constitutive activity that was inhibited by the non-peptide inverse agonist.
Data suggest that angiotensin converting enzyme 2 (show ACE2 Antibodies)/angiotensin II-(1-7)/MAS1 axis regulates leukocyte recruitment/activation, cell proliferation, and inflammation/fibrosis; main topic here is kidney/inflammatory renal disease. [REVIEW]
Up-regulation of the ACE2 (show ACE2 Antibodies)/Ang-(1 (show ANGPT1 Antibodies)-7)/Mas axis protected against pulmonary fibrosis by inhibiting the MAPK (show MAPK1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) pathway.
A proximal promoter construct for the MAS gene was repressed by the SOX (show PIPOX Antibodies) [SRY (show SRY Antibodies) (sex-determining region on the Y chromosome) box] proteins SRY (show SRY Antibodies), SOX2 (show SOX2 Antibodies), SOX3 (show SOX3 Antibodies) and SOX14 (show SOX14 Antibodies), of which SRY (show SRY Antibodies) is known to interact with the KRAB domain.
Mas appears to be a critical component required for NO-mediated vasodilatation induced by renin angiotensin system-dependent and RAS-independent agonists and therefore arises as a key pharmacological target to modulate endothelial function
MasR deficiency abolishes protection of female mice from obesity-induced hypertension
Results suggest that angiotensin converting enzyme 2 (show ACE2 Antibodies) may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala.
impairment of the ANG-(1 (show ANGPT1 Antibodies)-7)/Mas receptor pathway may lead to worsening of the pathophysiological changes of asthma.
The data indicate a significant function of Ang-(1 (show ANGPT1 Antibodies)-7) in the regulation of insulin (show INS Antibodies) secretion from mouse islets in vitro and in vivo, mainly, but not exclusively, by Mas-dependent signaling, modulating the accessory pathway of insulin (show INS Antibodies) secretion via increase in cAMP.
This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR.
Ang-(1 (show ANGPT1 Antibodies)-7)/Mas axis seems more important in autonomic modulation of arterial pressure than heart rate.
Mas receptor mediates cardioprotection of angiotensin-(1-7) against Ang II (show AGT Antibodies)-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress.
MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2 (show ACE2 Antibodies)-angiotensin-(1-7)-MAS axis functionality
Mas receptor deficiency results in exacerbated inflammation in LPS (show TLR4 Antibodies)-challenged mice, which suggest a potential role for the Mas receptor as a regulator of systemic and brain inflammatory response induced by LPS (show TLR4 Antibodies).
a Mas receptor-mediated mechanism may stimulate pancreatic cell development
oncogene\; may be involved in function or development of neural tissues
, MAS proto-oncogene
, angiotensin-(1-7) receptor
, MAS1 oncogene