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Human Renin Protein expressed in Human Cells - ABIN2003666
Imai, Miyazaki, Hirose, Hori, Hayashi, Kageyama, Ohkubo, Nakanishi, Murakami: Cloning and sequence analysis of cDNA for human renin precursor. in Proceedings of the National Academy of Sciences of the United States of America 1984
Show all 3 references for ABIN2003666
Mouse (Murine) Renin Protein expressed in Human Cells - ABIN2007609
Nguyen, Delarue, Burcklé, Bouzhir, Giller, Sraer: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. in The Journal of clinical investigation 2002
Show all 3 references for ABIN2007609
Human Renin Protein expressed in HEK-293 Cells - ABIN2181691
Adams, Beveridge, van der Weyden, Mangs, Leedman, Morris: HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. in The Journal of biological chemistry 2003
Results show negative regulation of HDAC1 (show HDAC1 Proteins) by a Cul3 (show CUL3 Proteins)-REN E3 ubiquitin ligase (show MUL1 Proteins) complex.
REN is upregulated by neurogenic signals (retinoic acid, EGF, and NGF) in embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation.
REN protein enhances caspase-3 (show CASP3 Proteins) activation and antagonizes the Shh (show SHH Proteins) pathway suggesting that this gene may represent a restraint of Shh (show SHH Proteins) signaling.
This study demonstrates the efficacy of aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism.
The dominant model (CC vs. CT+TT) of rs1894111 polymorphism in the ADRBK1 gene might be associated with low-renin hypertension in Han Chinese.
Data show that the optimum time for beta-adrenoreceptor antagonists (beta-blockers) withdrawal was 2 weeks when using direct renin concentration (DRC (show FECH Proteins)) and 3 weeks for plasma renin activity (PRA (show S100A6 Proteins)).
Active renin was not significantly different between hypertensive patients with and without left ventricular hypertrophy.
The present study provides evidence that the rs1464816 polymorphism in REN is associated with CKD progression in ADPKD.
Plasma renin and Aldosterone to renin ratio but not aldosterone are independently associated with presence of carotid plaques in coronary artery disease patients.
concentrations of serum aldosterone, plasma direct renin, and plasma renin activity were measured after a night's rest and again after walking for two hours.
Increased plasma renin, AT and VEGF might play a role in the onset or development of superficial infantile hemangiomas.
Elevated levels of circulating (pro)renin were observed in pre-eclampsia patients
The results suggest that variants in the enhancer region of the human renin gene have an effect on the expression levels of renin in renal tissue; this observation is in good accordance with the results of the transcriptional assay.
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
, BTB/POZ domain-containing protein KCTD11
, retinoic acid, EGF, and NGF upregulated
, renin 1 structural
, angiotensin-forming enzyme
, renin precursor, renal