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anti-Mouse (Murine) MAPKAP Kinase 2 Antibodies:
anti-Human MAPKAP Kinase 2 Antibodies:
anti-Rat (Rattus) MAPKAP Kinase 2 Antibodies:
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Human Polyclonal MAPKAP Kinase 2 Primary Antibody for DB, EIA - ABIN358152
Lukas, Kroe, Wildeson, Peet, Frego, Davidson, Ingraham, Pargellis, Labadia, Werneburg: Catalysis and function of the p38 alpha.MK2a signaling complex. in Biochemistry 2004
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Human Polyclonal MAPKAP Kinase 2 Primary Antibody for IF, IHC (p) - ABIN197078
Ben-Levy, Leighton, Doza, Attwood, Morrice, Marshall, Cohen: Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. in The EMBO journal 1996
Show all 2 references for 197078
Cow (Bovine) Polyclonal MAPKAP Kinase 2 Primary Antibody for IF (p), IHC (p) - ABIN681523
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
Show all 2 references for 681523
Human Polyclonal MAPKAP Kinase 2 Primary Antibody for IF, WB - ABIN197584
Rouse, Cohen, Trigon, Morange, Alonso-Llamazares, Zamanillo, Hunt, Nebreda: A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. in Cell 1994
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a p38 MAPKAPK2 kinase cascade modulates the activity of F-actin at the yolk cell margin circumference allowing the gradual closure of the blastopore as epiboly progresses
this study shows that the loss of MK2 (show KCNA2 Antibodies) in mast cells decreases the IL-33 (show IL33 Antibodies)-induced leukocyte recruitment and the resulting skin inflammation
MK2 (show KCNA2 Antibodies) signaling differentially regulated CCL3 (show CCL3 Antibodies) and CCL4 (show CCL4 Antibodies).
In silico analyses and experimental validation demonstrated that the kinase activity of p38(MAPK (show MAPK14 Antibodies)) determines signal amplitude, whereas phosphatase activity affects both signal amplitude and duration. p38(MAPK (show MAPK14 Antibodies)) and MK2 (show KCNA2 Antibodies) concentrations and responsiveness toward IL-1beta (show IL1B Antibodies) were quantitatively compared between hepatocytes and macrophages
MK2 (show KCNA2 Antibodies)-activating peptide (MK2 (show KCNA2 Antibodies)-AP) blocks the effects of anthrax lethal toxin on endothelial barriers in cultured cells and reduces pulmonary vascular leak in rats.
MK2 (show KCNA2 Antibodies) regulates postnatal arteriogenesis by controlling vascular recruitment of monocytes/macrophages in dual manner: regulation of endothelial MCP-1 (show CPT1B Antibodies) expression in response to hemodynamic and inflammatory forces as well as MCP-1 (show CPT1B Antibodies) dependent monocyte migration
these data suggest there is a sexual dimorphism in MK2 (show KCNA2 Antibodies) signaling of osteoclast progenitor cell subpopulations.
Loss of MK2 (show KCNA2 Antibodies) effectively blocks bone resorption and prevents the development of postmenopausal bone loss.
This study showed that cmpd28, a Mapkapk2/3 inhibitor, represents a potentially new approach to type 2 diabetes therapy.
Deficiency of MK2 (show KCNA2 Antibodies) prevents adverse remodelling and promotes endothelial healing of the arterial wall after injury.
high-fat diet-fed MK2 (show KCNA2 Antibodies)-/- mice display decreased glucose tolerance and increased insulin (show INS Antibodies) resistance compared to controls. Decreased adipose tissue expression of GLUT4 (show SLC2A4 Antibodies) might contribute to this phenotype.
According to the information mentioned above, we now report the design and synthesis of some series of new urea derivatives that were then evaluated for their inhibitory activities against MAPKAPK2, TNF-a (show TNF Antibodies), and p38a (show MAPK14 Antibodies)
MK2 (show KCNA2 Antibodies) post-transcriptionally regulates TNF-alpha (show TNF Antibodies)-induced ICAM-1 (show ICAM1 Antibodies) expression by altering the cytoplasmic localization of HuR (show ELAVL1 Antibodies) in human lung microvascular endothelial cells.
MK2 (show KCNA2 Antibodies) overexpression is associated with primary liver tumors.
CEP131 (show AZI1 Antibodies) is the key regulatory target of MK2 (show KCNA2 Antibodies) and 14-3-3 (show YWHAQ Antibodies) in centriolar satellite remodeling.
mTOR (show FRAP1 Antibodies) controls the senescence-associated secretory phenotype by differentially regulating the translation of the MK2 (show KCNA2 Antibodies) (also known as MAPKAPK2).
analysis of signaling cooperation between p38-MAPK (show MAPK14 Antibodies)/MAPKAP-2/Hsp27 (show HSPB1 Antibodies) and intracellular calcium release in AA-induced HBEC apoptosis
findings reveal MK2 (show KCNA2 Antibodies)/MK3 (show KCNA3 Antibodies) as crucial stress-responsive kinases that promote autophagy through Beclin 1 (show BECN1 Antibodies) S90 phosphorylation
The protein expression of both HMGB1 (show HMGB1 Antibodies) and MAPKAPK2 were increased in KLM1-R cells.
Data indicate the binding mode and molecular mechanism of action of MAPK-activated protein kinase-2 (MK2) and inhibitors.
Treatment with MK2 (show KCNA2 Antibodies) or p38 (show CRK Antibodies) inhibitors blocked human papillomavirus genome amplification, identifying the p38 (show CRK Antibodies)/MK2 (show KCNA2 Antibodies) pathway as a key regulator of the human papillomavirus life cycle.
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
MAP kinase-activated protein kinase 2
, betty boop
, mitogen-activated protein kinase-activated protein kinase 2
, MAPK-activated protein kinase 2
, MAPKAP kinase 2
, map kinase activated protein kinase-2