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Dimeric BCAP (show PHF11 Proteins) associates with the TIR domains of TLR2/4 and MAL/TIRAP (show TIRAP Proteins), suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions.
Abi-1 (show ABI1 Proteins) promotes Abl (show ABL1 Proteins)-mediated BCAP (show PHF11 Proteins) phosphorylation and suggest that Abi-1 (show ABI1 Proteins) in general coordinates kinase-substrate interactions
identify BCAP as a novel inhibitor of myelopoiesis in the steady state and of emergency myelopoiesis during demand conditions
Nck (show NCK1 Proteins)-mediated recruitment of BCAP to the BCR (show BCR Proteins) regulates the PI(3 (show PI3 Proteins))K-Akt (show AKT1 Proteins) pathway in B cells.
BCAP is an essential activator of the PI3K pathway downstream of TLR signaling.
BCAP is a unique TIR domain-containing toll (show TLR4 Proteins) like receptor (TLR) signaling adapter crucial for linking TLRs to PI3K activation and regulating the inflammatory response.
As macrophages engage their pathogenic targets, innate immune receptors trigger increased expression of BCAP, which endows them with the capacity to withstand further challenges from ongoing cellular insults, such as endoplasmic reticulum stress.
BCAP-(L) (but not BCAP-(S)) is a negative regulator of the TLR-mediated host defense system in macrophages.
BCAP and CD19 have complementary roles in BCR-mediated phosphoinositide 3-kinase activation
model in which blunting of BCAP-mediated activation signaling in developing NK cells promotes functionality, terminal maturation, and long-term survival
Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation (By similarity). May be involved in the survival of mature B-cells via activation of REL (By similarity).
B cell adaptor protein
, B-cell adapter for phosphoinositide 3-kinase
, B-cell phosphoinositide 3-kinase adapter protein 1
, phosphoinositide 3-kinase adapter protein 1
, B cell phosphoinositide 3-kinase adaptor