Browse our PFKFB3 Proteins (PFKFB3)

Full name:
6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 Proteins (PFKFB3)
On www.antibodies-online.com are 11 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) Proteins from 6 different suppliers available. Additionally we are shipping PFKFB3 Antibodies (85) and PFKFB3 Kits (1) and many more products for this protein. A total of 104 PFKFB3 products are currently listed.
Synonyms:
6-biphosphatase, 6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2, 6PF-2-K/Fru-2, E330010H22Rik, iPFK-2, IPFK2, PFK2, PFKFB3, uPFK-2, wu:fc31e01, zgc:73257
list all proteins Gene Name GeneID UniProt
PFKFB3 5209 Q16875
Mouse PFKFB3 PFKFB3 170768  
PFKFB3 117276 O35552

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PFKFB3 Proteins (PFKFB3) by Origin

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Top referenced PFKFB3 Proteins

  1. Human PFKFB3 Protein expressed in Baculovirus infected Insect Cells - ABIN2005593 : De Bock, Georgiadou, Schoors, Kuchnio, Wong, Cantelmo, Quaegebeur, Ghesquière, Cauwenberghs, Eelen, Phng, Betz, Tembuyser, Brepoels, Welti, Geudens, Segura, Cruys, Bifari, Decimo, Blanco, Wyns et al.: Role of PFKFB3-driven glycolysis in vessel sprouting. ... in Cell 2013 (PubMed)

More Proteins for PFKFB3 Interaction Partners

Zebrafish 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) interaction partners

  1. Study showed that endothelial cells (ECs)relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation.

Human 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) interaction partners

  1. Data suggest that hepatic glucokinase (show GCK Proteins) activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP (show GCKR Proteins)) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2/FBP2 (show KHSRP Proteins)); changes in glucokinase (show GCK Proteins) expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]

  2. PFKFB3 was a novel downstream substrate of mTOR (show FRAP1 Proteins) signaling pathway as PFKFB3 level was augmented after knocking down TSC2 in THP1 and OCI-AML3 (show RUNX2 Proteins) acute myeloid leukemia (show BCL11A Proteins) cells.

  3. Taken together, our study identifies PFKFB3 as a key TGFbeta1 (show TGFB1 Proteins) effector protein that mediates TGFbeta1 (show TGFB1 Proteins)'s effect on Snail (show SNAI1 Proteins) expression, invasion, and glycolysis.

  4. we investigate the crosstalk between PFKFB3 and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator (show C12orf5 Proteins)), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR (show C12orf5 Proteins) induction in HeLa cells in response to PFKFB3 knockdown

  5. Knockdown of PFKFB3 by siRNAs significantly inhibited the proliferation and migration abilities of gastric cancer cells. Our data suggest that PFKFB3 might be a potential biomarker for gastric cancer and anti-neoplastic targeting gene.

  6. The targeting of MCT1 (show CMA1 Proteins) and PFKFB3 regulated cell proliferation.

  7. the novel role of PFKFB3 in induction of paclitaxel resistance by raising lactate production and activating TLR4 (show TLR4 Proteins) signaling, was characterized.

  8. a novel role of PFKFB3 in glycolytic metabolism and ER stress of OA cartilage explants and chondrocytes

  9. Our data suggest that chronic inflammation promotes the development of CRC (show CALR Proteins) by stimulating aerobic glycolysis and IL-6 (show IL6 Proteins) is functioning, at least partly, through regulating PFKFB3 at early stage of colorectal cancer (CRC (show CALR Proteins)).

  10. MicroRNA-26b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB3 expression

Mouse (Murine) 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) interaction partners

  1. overexpression of PFKFB3 in HEK293 cells potentiated insulin (show INS Proteins)-dependent phosphorylation of Akt (show AKT1 Proteins) and Akt (show AKT1 Proteins) substrates

  2. Data show that inhibition of AMP (show TMPRSS5 Proteins)-Activated kinase (AMPK (show PRKAA1 Proteins)) or 6-phosphofructo-2-kinase-fructose-2,6-biphosphatase 3 (PFKFB3) results in enhanced cell death in mitosis.

  3. Shear stress-mediated repression of endothelial cell metabolism via KLF2 (show KLF2 Proteins) and PFKFB3 controls endothelial cell phenotype.

  4. PFKFB3 is a promising target for the reduction of endothelial glycolysis and its related pathological angiogenesis

  5. PFKFB3/iPFK2 responds to re-feeding, which in turn stimulates hypothalamic glycolysis and decreases hypothalamic AMPK (show PRKAA1 Proteins) phosphorylation and alters neuropeptide expression in a pattern that is associated with suppression of food intake.

  6. High-fat diet feeding stimulates intestine 6-phosphofructo-2-kinase expression and induces intestine inflammatory response.

  7. Study showed that endothelial cells (ECs)relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation.

  8. a unique role for PFKFB3/iPFK2 in adipocytes with regard to diet-induced inflammatory responses in both adipose and liver tissues.

  9. inducible PFKFB3 is required for increased growth, metabolic activity and is regulated through active JAK2 (show JAK2 Proteins) and STAT5 (show STAT5A Proteins).

  10. Cooperation of adenosine with macrophage Toll (show TLR4 Proteins)-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene.

PFKFB3 Protein Profile

Protein Summary

Synthesis and degradation of fructose 2,6-bisphosphate (By similarity).

Alternative names and synonyms associated with PFKFB3

  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (pfkfb3)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PTRG_09894)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (f263)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PGTG_20206)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Tsp_06710)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4)
  • 6-biphosphatase protein
  • 6-bisphosphatase protein
  • 6-phosphofructo-2-kinase/fructose-2 protein
  • 6PF-2-K/Fru-2 protein
  • E330010H22Rik protein
  • iPFK-2 protein
  • IPFK2 protein
  • PFK2 protein
  • PFKFB3 protein
  • uPFK-2 protein
  • wu:fc31e01 protein
  • zgc:73257 protein

Protein level used designations for PFKFB3

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 , 6-phosphofructo-2-kinase , fructose-2,6-biphosphatase 3 , 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 , 6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme , 6PF-2-K/Fru-2,6-P2ase 3 , PFK/FBPase 3 , 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-like , 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase , 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase , 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme , fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase , iPFK-2 , inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase , renal carcinoma antigen NY-REN-56 , inducible 6-phosphofructo-2-kinase , 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme , RB2K , 6-P2ase liver isozyme , 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase , 6PF-2-K/Fru-2,6-P2ase liver isozyme , PFK/FBPase

GENE ID SPECIES
418247 Gallus gallus
431861 Xenopus laevis
487139 Canis lupus familiaris
554477 Danio rerio
713062 Macaca mulatta
738397 Pan troglodytes
6348191 Pyrenophora tritici-repentis Pt-1C-BFP
100172898 Pongo abelii
100216216 Xenopus (Silurana) tropicalis
100350534 Oryctolagus cuniculus
100380757 Salmo salar
100414163 Callithrix jacchus
100464074 Ailuropoda melanoleuca
10535908 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10911737 Trichinella spiralis
100070251 Equus caballus
5209 Homo sapiens
170768 Mus musculus
117276 Rattus norvegicus
407183 Bos taurus
415906 Gallus gallus
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