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Browse our PFKFB3 Proteins (PFKFB3)

Full name:
6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 Proteins (PFKFB3)
On www.antibodies-online.com are 11 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) Proteins from 6 different suppliers available. Additionally we are shipping PFKFB3 Antibodies (80) and PFKFB3 Kits (4) and many more products for this protein. A total of 102 PFKFB3 products are currently listed.
Synonyms:
6-biphosphatase, 6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2, 6PF-2-K/Fru-2, E330010H22Rik, iPFK-2, IPFK2, PFK2, PFKFB3, uPFK-2, wu:fc31e01, zgc:73257
list all proteins Gene Name GeneID UniProt
PFKFB3 5209 Q16875
Mouse PFKFB3 PFKFB3 170768  
PFKFB3 117276 O35552

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PFKFB3 Proteins (PFKFB3) by Origin

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Top referenced PFKFB3 Proteins

  1. Human PFKFB3 Protein expressed in Baculovirus infected Insect Cells - ABIN2005593 : De Bock, Georgiadou, Schoors, Kuchnio, Wong, Cantelmo, Quaegebeur, Ghesquière, Cauwenberghs, Eelen, Phng, Betz, Tembuyser, Brepoels, Welti, Geudens, Segura, Cruys, Bifari, Decimo, Blanco, Wyns et al.: Role of PFKFB3-driven glycolysis in vessel sprouting. ... in Cell 2013 (PubMed)

More Proteins for PFKFB3 Interaction Partners

Zebrafish 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) interaction partners

  1. Study showed that endothelial cells (ECs)relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation.

Human 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) interaction partners

  1. Our data suggest that chronic inflammation promotes the development of CRC (show CALR Proteins) by stimulating aerobic glycolysis and IL-6 (show IL6 Proteins) is functioning, at least partly, through regulating PFKFB3 at early stage of colorectal cancer (CRC (show CALR Proteins)).

  2. MicroRNA-26b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB3 expression

  3. The expression of PFKFB3, PFKFB4 (show PFKFB4 Proteins), NAMPT (show NAMPT Proteins), and TSPAN13 (show TSPAN13 Proteins) is strongly up-regulated in pediatric glioma.

  4. Data indicate that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase3 (PFKFB3) and phosphofructokinase (PFK1 (show PFKM Proteins)) expression allows discrimination between induced pluripotent stem cells (iPS (show SLC27A4 Proteins)) and cancer stem cells (CSCs).

  5. Insulin (show INS Proteins) resistance in obese boys leads to up-regulation of INSIG2 (show INSIG2 Proteins) gene expression as well as to down-regulation of PFKFB1 (show PFKFB1 Proteins), PFKFB3, and HK2 (show HK2 Proteins) genes in the blood cells as compared to obese patients with normal insulin (show INS Proteins) sensitivity.

  6. A binding site for miR (show MLXIP Proteins)-26b was predicted in the 3'UTR of PFKFB3. miR (show MLXIP Proteins)-26b overexpression repressed PFKFB3 mRNA and protein levels.

  7. Data show that inhibition of AMP (show APRT Proteins)-Activated kinase (AMPK (show PRKAA1 Proteins)) or 6-phosphofructo-2-kinase-fructose-2,6-biphosphatase 3 (PFKFB3) results in enhanced cell death in mitosis.

  8. Shh (show SHH Proteins) regulates PFKFB3 activation in breast cancer cells.

  9. study demonstrated that miR (show MLXIP Proteins)-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration

  10. PFKFB3 promotes cell cycle progression and suppresses apoptosis via Cdk1 (show CDK1 Proteins)-mediated phosphorylation of p27 (show PAK2 Proteins).

Mouse (Murine) 6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3) interaction partners

  1. overexpression of PFKFB3 in HEK293 cells potentiated insulin (show INS Proteins)-dependent phosphorylation of Akt (show AKT1 Proteins) and Akt (show AKT1 Proteins) substrates

  2. Data show that inhibition of AMP (show TMPRSS5 Proteins)-Activated kinase (AMPK (show PRKAA1 Proteins)) or 6-phosphofructo-2-kinase-fructose-2,6-biphosphatase 3 (PFKFB3) results in enhanced cell death in mitosis.

  3. Shear stress-mediated repression of endothelial cell metabolism via KLF2 (show KLF2 Proteins) and PFKFB3 controls endothelial cell phenotype.

  4. PFKFB3 is a promising target for the reduction of endothelial glycolysis and its related pathological angiogenesis

  5. PFKFB3/iPFK2 responds to re-feeding, which in turn stimulates hypothalamic glycolysis and decreases hypothalamic AMPK (show PRKAA1 Proteins) phosphorylation and alters neuropeptide expression in a pattern that is associated with suppression of food intake.

  6. High-fat diet feeding stimulates intestine 6-phosphofructo-2-kinase expression and induces intestine inflammatory response.

  7. Study showed that endothelial cells (ECs)relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation.

  8. a unique role for PFKFB3/iPFK2 in adipocytes with regard to diet-induced inflammatory responses in both adipose and liver tissues.

  9. inducible PFKFB3 is required for increased growth, metabolic activity and is regulated through active JAK2 (show JAK2 Proteins) and STAT5 (show STAT5A Proteins).

  10. Cooperation of adenosine with macrophage Toll (show TLR4 Proteins)-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene.

PFKFB3 Protein Profile

Protein Summary

Synthesis and degradation of fructose 2,6-bisphosphate (By similarity).

Alternative names and synonyms associated with PFKFB3

  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (pfkfb3)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PTRG_09894)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (f263)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PGTG_20206)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Tsp_06710)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3)
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4)
  • 6-biphosphatase protein
  • 6-bisphosphatase protein
  • 6-phosphofructo-2-kinase/fructose-2 protein
  • 6PF-2-K/Fru-2 protein
  • E330010H22Rik protein
  • iPFK-2 protein
  • IPFK2 protein
  • PFK2 protein
  • PFKFB3 protein
  • uPFK-2 protein
  • wu:fc31e01 protein
  • zgc:73257 protein

Protein level used designations for PFKFB3

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 , 6-phosphofructo-2-kinase , fructose-2,6-biphosphatase 3 , 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 , 6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme , 6PF-2-K/Fru-2,6-P2ase 3 , PFK/FBPase 3 , 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-like , 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase , 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase , 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme , fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase , iPFK-2 , inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase , renal carcinoma antigen NY-REN-56 , inducible 6-phosphofructo-2-kinase , 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme , RB2K , 6-P2ase liver isozyme , 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase , 6PF-2-K/Fru-2,6-P2ase liver isozyme , PFK/FBPase

GENE ID SPECIES
418247 Gallus gallus
431861 Xenopus laevis
487139 Canis lupus familiaris
554477 Danio rerio
713062 Macaca mulatta
738397 Pan troglodytes
6348191 Pyrenophora tritici-repentis Pt-1C-BFP
100172898 Pongo abelii
100216216 Xenopus (Silurana) tropicalis
100350534 Oryctolagus cuniculus
100380757 Salmo salar
100414163 Callithrix jacchus
100464074 Ailuropoda melanoleuca
10535908 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10911737 Trichinella spiralis
100070251 Equus caballus
5209 Homo sapiens
170768 Mus musculus
117276 Rattus norvegicus
407183 Bos taurus
415906 Gallus gallus
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