Histone Deacetylase 1 (HDAC1) (Internal Region) antibody

Details for Product No. ABIN1043884, Supplier: Log in to see
Antigen
  • HD1
  • RPD3
  • Hdac1
  • Gm1824
  • EG15181
  • Hdac1-ps
  • ENSMUSG00000061062
  • Rpd3
  • GB14706
  • hdac1
  • rpd3
  • yaf1
  • gon-10
  • hdac1-b
  • rpd3l1
  • ARABIDOPSIS HISTONE DEACETYLASE 1
  • ARABIDOPSIS HISTONE DEACETYLASE 19
  • ATHD1
  • ATHDA19
  • ATRPD3A
  • F20D10.250
  • F20D10_250
  • HDA1
  • HDA19
  • HISTONE DEACETYLASE
  • HISTONE DEACETYLASE 19
  • HISTONE DEACETYLASE19
  • RPD3A
  • histone deacetylase 1
  • CG7471
  • DHDAC1
  • DRpd3
  • DmHDAC1
  • Dmel\\CG7471
  • E(var)3-64BC
  • HDAC
  • HDAC-1
  • HDAC1
  • Rpd3/HDAC
  • Su(var)3-26
  • Su(var)326
  • Su(var)328
  • dHDAC-1
  • dHDAC1
  • dRPD3
  • dRpd3
  • dmHDA401
  • drpd3
  • l(3)04556
  • l(3)64Cc
  • rpd[3]
  • GON-10
  • RPD3L1
  • MommeD5
  • chunp6919
  • hdac-1
  • mp:zf637-2-001987
  • wu:fb19h11
  • wu:fi06f03
  • zgc:101582
  • zgc:65818
  • hdac1b
  • histone deacetylase 1 pseudogene
  • histone deacetylase
  • histone deacetylase 1
  • histone deacetylase 2
  • histone deacetylase 1-like
  • histone deacetylase 19
  • CG7471 gene product from transcript CG7471-RA
  • Gm10093
  • HDAC1
  • hdac2
  • hdac1
  • Hdac1l
  • HD1
  • Rpd3
  • Hdac1
  • hdac1-b
Alternatives
anti-Dog (Canine) Histone Deacetylase 1 antibody for Immunohistochemistry (Frozen Sections)
Epitope
Internal Region
84
29
29
23
22
19
12
12
12
11
11
11
10
8
8
8
8
7
5
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
397
197
172
17
16
15
12
10
9
7
6
6
4
4
2
2
1
1
1
Host
Rabbit
294
93
21
Clonality
Polyclonal
Conjugate
Un-conjugated
12
12
11
11
11
11
2
2
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
364
197
114
111
87
45
33
19
17
12
7
4
4
4
4
3
2
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Anti-HDAC-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 466-482 of Human HDAC-1.
Immunogen Type: Peptide
Isotype IgG
Specificity Anti-HDAC-1 antibody is directed against human HDAC-1 protein. HDAC-1 antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from human, mouse, rat and chimpanzee sources based on 100% homology for the immunogen sequence. Cross reactivity may occur with HDAC-1 from bovine (82% homology) and chicken (80% homology) sources. Cross reactivity with HDAC-1 homologues from other sources has not been determined.
Characteristics HDAC-1 antibody recognizes HDAC1 (also known as HD1, histone deacetylase 1, RPD3, RPD3L1) which belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Sterility Sterile filtered
Alternative Name HDAC-1 (HDAC1 Antibody Abstract)
Background HDAC-1 antibody recognizes HDAC1 (also known as HD1, histone deacetylase 1, RPD3, RPD3L1) which belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Synonyms: GON 10 antibody, HD 1 antibody, hdac1: histone deacetylase 1 antibody, Histone deacetylase 1 (HD1) antibody, Histone deacetylase 1 antibody, RPD3 (reduced potassium dependency yeast homolog) like 1 antibody
Gene ID 3065, 13128860
UniProt Q13547
Research Area DNA/RNA, Transcription Factors
Pathways Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling
Application Notes Anti-HDAC-1 Antibody has been tested for use in ELISA, immunohistochemistry and western blot. Specific conditions for reactivity should be optimized by the end user. Specific nuclear staining is observed by IHC. Expect bands at 65 kDa in size corresponding to HDAC-1 by western blotting in the appropriate cell lysate or extract.
Comment

Gene Name: HDAC1

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Histone Deacetylase 1 (HDAC1) (Internal Region) antibody (ABIN1043884) Immunohistochemistry of Rabbit Anti-HDAC-1 Antibody. Tissue: human prostate cancer ti...
 image for anti-Histone Deacetylase 1 (HDAC1) (Internal Region) antibody (ABIN1043884) anti-Histone Deacetylase 1 (HDAC1) (Internal Region) antibody (Image 2)
Product cited in: Unoki, Nishidate, Nakamura: "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." in: Oncogene, Vol. 23, Issue 46, pp. 7601-10, 2004 (PubMed).

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