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Histone Deacetylase 1 (HDAC1) (Internal Region) antibody

Details for Product No. ABIN1043884, Supplier: Log in to see
Antigen
  • HD1
  • RPD3
  • Hdac1
  • Gm1824
  • EG15181
  • Hdac1-ps
  • ENSMUSG00000061062
  • Rpd3
  • GB14706
  • hdac1
  • rpd3
  • yaf1
  • gon-10
  • hdac1-b
  • rpd3l1
  • ARABIDOPSIS HISTONE DEACETYLASE 1
  • ARABIDOPSIS HISTONE DEACETYLASE 19
  • ATHD1
  • ATHDA19
  • ATRPD3A
  • F20D10.250
  • F20D10_250
  • HDA1
  • HDA19
  • HISTONE DEACETYLASE
  • HISTONE DEACETYLASE 19
  • HISTONE DEACETYLASE19
  • RPD3A
  • histone deacetylase 1
  • CG7471
  • DHDAC1
  • DRpd3
  • DmHDAC1
  • Dmel\\CG7471
  • E(var)3-64BC
  • HDAC
  • HDAC-1
  • HDAC1
  • Rpd3/HDAC
  • Su(var)3-26
  • Su(var)326
  • Su(var)328
  • dHDAC-1
  • dHDAC1
  • dRPD3
  • dRpd3
  • dmHDA401
  • drpd3
  • l(3)04556
  • l(3)64Cc
  • rpd[3]
  • GON-10
  • RPD3L1
  • MommeD5
  • chunp6919
  • hdac-1
  • mp:zf637-2-001987
  • wu:fb19h11
  • wu:fi06f03
  • zgc:101582
  • zgc:65818
  • hdac1b
Alternatives
anti-Human Histone Deacetylase 1 antibody for Immunohistochemistry (Frozen Sections)
Epitope
Internal Region
88
32
25
22
18
18
18
15
10
10
10
10
9
9
8
8
8
5
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
359
139
122
11
9
5
5
5
4
3
2
2
2
2
1
1
1
1
1
1
1
1
Host
Rabbit
280
76
18
Clonality
Polyclonal
Conjugate
Un-conjugated
10
10
10
10
10
10
3
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
323
188
102
98
62
41
21
16
12
10
6
4
4
3
1
1
1
1
1
Supplier
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Immunogen Anti-HDAC-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 466-482 of Human HDAC-1.
Immunogen Type: Peptide
Isotype IgG
Specificity Anti-HDAC-1 antibody is directed against human HDAC-1 protein. HDAC-1 antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from human, mouse, rat and chimpanzee sources based on 100% homology for the immunogen sequence. Cross reactivity may occur with HDAC-1 from bovine (82% homology) and chicken (80% homology) sources. Cross reactivity with HDAC-1 homologues from other sources has not been determined.
Characteristics HDAC-1 antibody recognizes HDAC1 (also known as HD1, histone deacetylase 1, RPD3, RPD3L1) which belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Sterility Sterile filtered
Alternative Name HDAC-1 (HDAC1 Antibody Abstract)
Background HDAC-1 antibody recognizes HDAC1 (also known as HD1, histone deacetylase 1, RPD3, RPD3L1) which belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Synonyms: GON 10 antibody, HD 1 antibody, hdac1: histone deacetylase 1 antibody, Histone deacetylase 1 (HD1) antibody, Histone deacetylase 1 antibody, RPD3 (reduced potassium dependency yeast homolog) like 1 antibody
Gene ID 3065, 13128860
UniProt Q13547
Research Area DNA/RNA, Transcription Factors
Pathways Neurotrophin Signaling Pathway
Application Notes Anti-HDAC-1 Antibody has been tested for use in ELISA, immunohistochemistry and western blot. Specific conditions for reactivity should be optimized by the end user. Specific nuclear staining is observed by IHC. Expect bands at 65 kDa in size corresponding to HDAC-1 by western blotting in the appropriate cell lysate or extract.
Comment

Gene Name: HDAC1

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Histone Deacetylase 1 (HDAC1) (Internal Region) antibody (ABIN1043884) Immunohistochemistry of Rabbit Anti-HDAC-1 Antibody. Tissue: human prostate cancer ti...
 image for anti-Histone Deacetylase 1 (HDAC1) (Internal Region) antibody (ABIN1043884) anti-Histone Deacetylase 1 (HDAC1) (Internal Region) antibody (Image 2)
Product cited in: Unoki, Nishidate, Nakamura: "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain." in: Oncogene, Vol. 23, Issue 46, pp. 7601-10, 2004 (PubMed).