PLA1A antibody (C-Term)
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- Target See all PLA1A Antibodies
- PLA1A (Phospholipase A1 Member A (PLA1A))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PLA1A antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Specificity
- At least three isoforms of PLA1A are known to exist, this antibody will detect all three isoforms.
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- PLA1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human PLA1A.
- Isotype
- IgG
- Top Product
- Discover our top product PLA1A Primary Antibody
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- Application Notes
- PLA1A antibody can be used for detection of PLA1A by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
- Comment
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(CT) Phospholipase A1 member A
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Storage
- 4 °C
- Storage Comment
- PLA1A antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.
- Expiry Date
- 12 months
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- Target
- PLA1A (Phospholipase A1 Member A (PLA1A))
- Alternative Name
- PLA1A (PLA1A Products)
- Synonyms
- PS-PLA1 antibody, PSPLA1 antibody, AA986889 antibody, Ps-pla1 antibody, Pspla1 antibody, wu:fi26h09 antibody, zgc:77160 antibody, AH antibody, ARWH2 antibody, LAH2 antibody, LPDLR antibody, PLA1B antibody, mPA-PLA1 antibody, phospholipase A1 member A antibody, lipase H antibody, PLA1A antibody, Pla1a antibody, pla1a antibody, CpipJ_CPIJ002492 antibody, CpipJ_CPIJ007883 antibody, LIPH antibody
- Background
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PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.
Synonyms: Phospholipase A1 member A, phosphatidylserine-specific phospholipase A1, PS-PLA1 - Molecular Weight
- 50 kDa
- Gene ID
- 51365
- NCBI Accession
- NP_056984
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