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Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 12-280) antibody

Details for Product No. ABIN108541, Supplier: Log in to see
Antigen
  • sip1
  • sip1-delta
  • SIP1
  • SIP1-delta
  • 1700012N19Rik
  • Sip1
  • HSPC082
  • SIP-1
  • SMADIP1
  • ZFHX1B
  • gem (nuclear organelle) associated protein 2
  • zinc finger E-box binding homeobox 2
  • gemin2
  • GEMIN2
  • Gemin2
  • ZEB2
Epitope
AA 12-280
12
7
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Human, Xenopus laevis
79
54
48
3
2
2
2
2
1
1
1
1
1
Host
Mouse
68
13
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blotting (WB)
62
23
21
19
14
13
9
5
2
2
1
1
Options
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Immunogen His-Gemin 2 fusion protein (amino acids 12 - 280, starting at 2nd methionine)
Clone 2E17
Isotype IgG1
Purification Protein A
Alternative Name Gemin 2 (GEMIN2 Antibody Abstract)
Background Synonyms:
Component of gems 2 antibody,GEMI2_HUMAN antibody,Gemin-2 antibody,gemin2 antibody,SIP 1antibody,SIP-1 antibody,SIP1 antibody,SIP1 delta antibody,SMN interacting protein 1 antibody,SMNinteracting protein 1 delta antibody,SMN-interacting protein 1 antibody,Survival interacting protein 1antibody,Survival of motor neuron protein interacting protein 1 antibody,Survival of motor neuronprotein-interacting protein 1 antibody
Gene ID 8487, 66603
OMIM 602595
UniProt O42260
Research Area Neurology
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try: Flow Cyt: Use 1 μg for 106 cell WB: Use at an assay dependent dilution. Detects a band of approximately 34 kDa
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Purified antibody (from supernatant) containing PBS 0.1 % sodium azide,
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
 image for anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 12-280) antibody (ABIN108541) anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 12-280) antibody
 image for anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 12-280) antibody (ABIN108541) anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 12-280) antibody (Image 2)
Product cited in: Sanchez, Dury, Murray, Biondi, Tadesse, El Fatimy, Kothary, Charbonnier, Khandjian, Côté: "A novel function for the survival motoneuron protein as a translational regulator." in: Human molecular genetics, Vol. 22, Issue 4, pp. 668-84, 2013 (PubMed).

Wu, Whye, Glazewski, Choe, Kerr, Lee, Mason, Wang: "Proteomic assessment of a cell model of spinal muscular atrophy." in: BMC neuroscience, Vol. 12, pp. 25, 2011 (PubMed).

Takizawa, Qing, Takaku, Ishida, Morozumi, Tsujita, Kogame, Hirota, Takahashi, Shibata, Kurumizaka, Takeda: "GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination." in: Nucleic acids research, Vol. 38, Issue 15, pp. 5059-74, 2010 (PubMed).

Burnett, Muñoz, Tandon, Kwon, Sumner, Fischbeck: "Regulation of SMN protein stability." in: Molecular and cellular biology, Vol. 29, Issue 5, pp. 1107-15, 2009 (PubMed).

Walker, Rajendra, Saieva, Fuentes, Pellizzoni, Matera: "SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain." in: Human molecular genetics, Vol. 17, Issue 21, pp. 3399-410, 2008 (PubMed).

Morency, Sabra, Catez, Texier, Lomonte: "A novel cell response triggered by interphase centromere structural instability." in: The Journal of cell biology, Vol. 177, Issue 5, pp. 757-68, 2007 (PubMed).

Renvoisé, Khoobarry, Gendron, Cibert, Viollet, Lefebvre: "Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells." in: Journal of cell science, Vol. 119, Issue Pt 4, pp. 680-92, 2006 (PubMed).

Liu, Fischer, Wang, Dreyfuss: "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins." in: Cell, Vol. 90, Issue 6, pp. 1013-21, 1997 (PubMed).