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SIP1 antibody (AA 12-280)

GEMIN2 Reactivity: Human, Mouse, Xenopus laevis WB, ELISA, IF, IP, ICC, FACS Host: Mouse Monoclonal 2E17 unconjugated
Catalog No. ABIN108540
  • Target See all SIP1 (GEMIN2) Antibodies
    SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))
    Binding Specificity
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 12-280
    Reactivity
    • 37
    • 24
    • 24
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Xenopus laevis
    Host
    • 34
    • 4
    Mouse
    Clonality
    • 35
    • 3
    Monoclonal
    Conjugate
    • 21
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIP1 antibody is un-conjugated
    Application
    • 18
    • 14
    • 9
    • 8
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Purification
    Protein A
    Immunogen
    His-Gemin 2 fusion protein (amino acids 12 - 280, starting at 2nd methionine)
    Clone
    2E17
    Isotype
    IgG1
    Top Product
    Discover our top product GEMIN2 Primary Antibody
  • Application Notes
    Optimal antibody dilution should be determined by titration, however as a guideline try:Flow Cyt: Use 1 μg for 106 cellWB: Use at an assay dependent dilution. Detects a band of approximately 34 kDa
    Comment

    Myeloma, fusion partners: SP2/0

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Purified antibody (from supernatant) containing PBS + 0.1 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
  • Sanchez, Dury, Murray, Biondi, Tadesse, El Fatimy, Kothary, Charbonnier, Khandjian, Côté: "A novel function for the survival motoneuron protein as a translational regulator." in: Human molecular genetics, Vol. 22, Issue 4, pp. 668-84, (2013) (PubMed).

    Wu, Whye, Glazewski, Choe, Kerr, Lee, Mason, Wang: "Proteomic assessment of a cell model of spinal muscular atrophy." in: BMC neuroscience, Vol. 12, pp. 25, (2011) (PubMed).

    Takizawa, Qing, Takaku, Ishida, Morozumi, Tsujita, Kogame, Hirota, Takahashi, Shibata, Kurumizaka, Takeda: "GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination." in: Nucleic acids research, Vol. 38, Issue 15, pp. 5059-74, (2010) (PubMed).

    Burnett, Muñoz, Tandon, Kwon, Sumner, Fischbeck: "Regulation of SMN protein stability." in: Molecular and cellular biology, Vol. 29, Issue 5, pp. 1107-15, (2009) (PubMed).

    Walker, Rajendra, Saieva, Fuentes, Pellizzoni, Matera: "SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain." in: Human molecular genetics, Vol. 17, Issue 21, pp. 3399-410, (2008) (PubMed).

    Morency, Sabra, Catez, Texier, Lomonte: "A novel cell response triggered by interphase centromere structural instability." in: The Journal of cell biology, Vol. 177, Issue 5, pp. 757-68, (2007) (PubMed).

    Renvoisé, Khoobarry, Gendron, Cibert, Viollet, Lefebvre: "Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells." in: Journal of cell science, Vol. 119, Issue Pt 4, pp. 680-92, (2006) (PubMed).

    Liu, Fischer, Wang, Dreyfuss: "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins." in: Cell, Vol. 90, Issue 6, pp. 1013-21, (1997) (PubMed).

  • Target
    SIP1 (GEMIN2) (Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))
    Alternative Name
    Gemin 2 (GEMIN2 Products)
    Synonyms
    SIP1 antibody, SIP1-delta antibody, 1700012N19Rik antibody, Sip1 antibody, sip1 antibody, sip1-delta antibody, wu:fc52a05 antibody, zgc:110274 antibody, gem nuclear organelle associated protein 2 antibody, gem (nuclear organelle) associated protein 2 antibody, gem nuclear organelle associated protein 2 S homeolog antibody, GEMIN2 antibody, Gemin2 antibody, gemin2.S antibody, gemin2 antibody
    Background
    Synonyms:
    Component of gems 2 antibody,GEMI2_HUMAN antibody,Gemin-2 antibody,gemin2 antibody,SIP 1antibody,SIP-1 antibody,SIP1 antibody,SIP1 delta antibody,SMN interacting protein 1 antibody,SMNinteracting protein 1 delta antibody,SMN-interacting protein 1 antibody,Survival interacting protein 1antibody,Survival of motor neuron protein interacting protein 1 antibody,Survival of motor neuronprotein-interacting protein 1 antibody
    Gene ID
    8487
    OMIM
    602595
    Pathways
    Ribonucleoprotein Complex Subunit Organization, Tube Formation
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