IL13 Receptor alpha 1 antibody (Extracellular Domain)

Catalog No. ABIN108718

This Mouse Monoclonal antibody specifically detects IL13 Receptor alpha 1 in ELISA, FACS, cELISA and Anta. It exhibits reactivity toward Human.

Quick Overview for IL13 Receptor alpha 1 antibody (Extracellular Domain) (ABIN108718)

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL13 Receptor alpha 1 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Cell-ELISA (cELISA), Antagonist (Anta)

Clone: GM-1E7

Product Details anti-IL13 Receptor alpha 1 Antibody

Binding Specificity: Extracellular Domain

Specificity: GM1E7 recognises IL-13Ralpha1 transiently expressed on the cell surface of transfected BOSC cells as well as the native protein on monocytes (Myrtek et al., 2004).

Purification: Protein G

Immunogen: genetic immunisation with cDNA encoding human IL13-Ralpha1 (extracellular domain)

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C

Storage Comment: short term: 2 °C - 8 °C, long term: -20 °C

Target Details for IL13 Receptor alpha 1

Target: IL13 Receptor alpha 1 (IL13RA1) (Interleukin 13 Receptor, alpha 1 (IL13RA1))

Alternative Name: IL13Ra1

Background: Interleukin 13 (IL-13) is a T cell derived cytokine involved in the regulation of inflammatory and im-mune responses. IL-13Rα1 together with IL-4Rα forms a functional receptor for both IL-4 and IL-13, which is why these two cytokines share many of their biological activities. The receptor is found on human B cells, monocytes and endothelial cells. However, no functional receptor is expressed on T cells, which explains why IL-13, in contrast to IL-4, fails to induce TH2-cell differentiation.

UniProt: P78552

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response