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CEACAM5 antibody (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5)

Details for Product anti-CEACAM5 Antibody No. ABIN108727, Supplier: Log in to see
Antigen
  • CEACAM5
  • CEA
  • CEACAM
  • RGD1311281
  • CD66e
  • 1600029H12Rik
  • Psg30
  • carcinoembryonic antigen-related cell adhesion molecule 5
  • carcinoembryonic antigen
  • carcinoembryonic antigen-related cell adhesion molecule 20
  • CEACAM5
  • Ceacam20
  • Ceacam5
Reactivity
Human
434
71
10
8
Host
Mouse
368
64
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CEACAM5 antibody is un-conjugated
18
15
12
12
12
12
12
12
12
11
11
11
11
11
10
10
10
7
1
1
1
1
Application
Cell-ELISA (cELISA), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB)
260
236
138
103
83
70
70
32
28
17
15
8
7
7
3
2
1
1
1
1
1
1
1
Options
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Available images

Immunogen immunisation with extracted protein of CEACAM5
Clone 26-3-13
Isotype IgG1
Specificity Anti-human CEACAM5 (CEA, CD66e)
Purification Protein G
Alternative Name CEACAM5 (CEACAM5 Antibody Abstract)
Background CEACAM5 or CEA is the name-giving member of the CEACAM family. CEACAM5 is used as a tumor marker for early detection of recurrent disease and is a potential target of tumor imaging, drugs and immunotargeting. 26/3/13 can be used to distinguish CEACAM5 from all other CEACAM and probably all pregnancy-specific glycoproteins molecules.
UniProt P06731
Research Area Cancer
Application Notes Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 Western Blot: 4 µg/mL
Immunohistology: 1-2 µg/10^6 cells (on cryosections)
For each application a titration should be performed to determine the optimal concentration.
Comment

Synonyms: CD66e, CEA

Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C
Storage Comment short term: 2 °C - 8 °C, long term: -20 °C
Supplier Images
 image for anti-CEACAM5 antibody (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5) (ABIN108727) Specificity testing of 26/3/13. Members of the CEA family were expressed on BOSC cell...
 image for anti-CEACAM5 antibody (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5) (ABIN108727) FACS analysis of BOSC23 cells using 26/3/13. BOSC23 cells were transiently transfecte...
Flow Cytometry (FACS) image for anti-CEACAM5 antibody (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5) (ABIN108727) FACS analysis of BOSC23 cells using 26/3/13. BOSC23 cells were transiently transfecte...
Flow Cytometry (FACS) image for anti-CEACAM5 antibody (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5) (ABIN108727) Specificity testing of 26/3/13. BOSC23 cells were transiently transfected with expres...
Background publications Partyka, McDonald, Maupin, Brand, Kwon, Simeone, Allen, Haab: "Comparison of surgical and endoscopic sample collection for pancreatic cyst fluid biomarker identification." in: Journal of proteome research, Vol. 11, Issue 5, pp. 2904-11, 2012 (PubMed).

Drukker, Tang, Ardehali, Rinkevich, Seita, Lee, Mosley, Weissman, Soen: "Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells." in: Nature biotechnology, Vol. 30, Issue 6, pp. 531-42, 2012 (PubMed).

Peng, Oberst, Huang, Brohawn, Morehouse, Lekstrom, Baeuerle, Wu, Yao, Coats, DallAcqua, Damschroder, Hammond: "The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA." in: PLoS ONE, Vol. 7, Issue 5, pp. e36412, 2012 (PubMed).

Nöckel, van den Engel, Winter, Hatz, Zimmermann, Kammerer: "Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene." in: BMC cancer, Vol. 6, pp. 57, 2006 (PubMed).

Schmitter, Agerer, Peterson, Munzner, Hauck: "Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens." in: The Journal of experimental medicine, Vol. 199, Issue 1, pp. 35-46, 2004 (PubMed).

Kammerer, Riesenberg, Weiler, Lohrmann, Schleypen, Zimmermann: "The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma." in: The Journal of pathology, Vol. 204, Issue 3, pp. 258-67, 2004 (PubMed).

Baczy?ska, Wietrzyk, Madej, Krop-Watorek, Dabrowska, Widerak, Opolski, Ugorski: "The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression." in: Cellular & molecular biology letters, Vol. 8, Issue 2, pp. 471-86, 2003 (PubMed).

Schölzel, Zimmermann, Schwarzkopf, Grunert, Rogaczewski, Thompson: "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas." in: The American journal of pathology, Vol. 156, Issue 2, pp. 595-605, 2000 (PubMed).

Krop-Watorek, Laskowska, Salwa, Kłopocki, Grunert, Ugorski: "CEA-related proteins on human urothelial cell lines of different transformation grades." in: Cancer letters, Vol. 139, Issue 1, pp. 15-22, 1999 (PubMed).

Hammarström: "The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues." in: Seminars in cancer biology, Vol. 9, Issue 2, pp. 67-81, 1999 (PubMed).

Thompson, Mössinger, Reichardt, Engels, Beauchemin, Kommoss, von Kleist, Zimmermann: "A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members." in: International journal of cancer. Journal international du cancer, Vol. 55, Issue 2, pp. 311-9, 1993 (PubMed).

Strobel, Strobel, Bross, Winterhalter, Fiebig, Schildge, Loehr: "Effects of human bone marrow stroma on the growth of human tumor cells." in: Cancer research, Vol. 49, Issue 4, pp. 1001-7, 1989 (PubMed).

Grunert, AbuHarfeil, Schwarz, von Kleist: "Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns." in: International journal of cancer. Journal international du cancer, Vol. 36, Issue 3, pp. 357-62, 1985 (PubMed).

Product cited in: Saeland, Belo, Mongera, van Die, Meijer, van Kooyk: "Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients." in: International journal of cancer. Journal international du cancer, 2011 (PubMed).