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ACIN1 antibody (Apoptotic Chromatin Condensation Inducer 1) (N-Term)

Details for Product anti-ACIN1 Antibody No. ABIN1105223, Supplier: Log in to see
Antigen
  • 2610036I19Rik
  • 2610510L13Rik
  • ACINUS
  • acinus
  • Acinus
  • acinusa
  • acinusb
  • acinusL
  • acinusl
  • acinusS
  • Acn
  • acn
  • ACN
  • C79325
  • fi14c05
  • fSAP152
  • ik:tdsubc_2g5
  • mKIAA0670
  • si:zc14a17.12
  • wu:fb04g06
  • wu:fb40f03
  • wu:fb68h03
  • wu:fb80f07
  • wu:fc12e10
  • wu:fe06a10
  • wu:fi14c05
  • xx:tdsubc_2g5
Epitope
N-Term, AA 1-523
33
19
13
13
9
6
5
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
127
33
21
1
Host
Mouse
123
8
Clonality (Clone)
Monoclonal ()
Conjugate
This ACIN1 antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Western Blotting (WB)
112
45
24
17
13
12
12
6
4
3
3
2
1
Supplier
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Immunogen GST-human AcinusL fusion protein corresponding to N-terminal amino acids (1~523 a.a.)
Clone 3H8
Isotype IgG1
Specificity This antibody reacts withAcinusL.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Does not react with mouse (WR19L, NIH3T3) or hamster (CHO).
Purification Protein A agarose beads
Alternative Name Acinus / ACIN1 (ACIN1 Antibody Abstract)
Background Chromatin condensation and nuclear fragmentation (CCNF) are hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase-activated DNase (CAD/DFF40) and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (Apoptotic Chromatin Condensation Inducer in the Nucleus). The 220 kDa Acinus protein is cleaved by caspase-3 and an additional unknown protease to generate a 17 kDa peptide that which causes chromatin condensation in vitro when added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS, and AcinusS'. Acinus is ubiquitously expressed.Synonyms: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670
Molecular Weight 220 kDa
Gene ID 22985
NCBI Accession NP_001158286
UniProt Q9UKV3
Research Area Cell Cycle, Apoptosis/Necrosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-ACIN1 antibody (Apoptotic Chromatin Condensation Inducer 1) (N-Term) (ABIN1105223) anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (AA 1-523), (N-Term) antibody
Western Blotting (WB) image for anti-ACIN1 antibody (Apoptotic Chromatin Condensation Inducer 1) (N-Term) (ABIN1105223) anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (AA 1-523), (N-Term) antibody (Image 2)
Background publications Sahara, Aoto, Eguchi, Imamoto, Yoneda, Tsujimoto: "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation." in: Nature, Vol. 401, Issue 6749, pp. 168-73, 1999