BHMT antibody (Betaine--Homocysteine S-Methyltransferase) (AA 1-406)

Details for Product anti-BHMT Antibody No. ABIN1105529, Supplier: Log in to see
Antigen
  • BHMT1
  • hm:zehn2153
  • wu:fb53h01
  • wu:fb63c08
  • wu:fj64d01
  • zgc:123027
  • betaine--homocysteine S-methyltransferase
  • betaine-homocysteine methyltransferase
  • betaine-homocysteine S-methyltransferase
  • BHMT
  • bhmt
  • Bhmt
Alternatives
anti-Human BHMT antibody for Enzyme Immunoassay
Epitope
AA 1-406, N-Term
27
18
3
3
3
2
1
1
1
1
1
1
Reactivity
Human
111
25
24
19
12
4
4
4
3
3
3
3
2
2
1
1
Host
Mouse
77
37
20
Clonality (Clone)
Monoclonal ()
Conjugate
This BHMT antibody is un-conjugated
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
124
65
53
25
25
14
8
2
1
1
1
Options
Supplier
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Immunogen Recombinant Human BHMT (amino acids 1-406) purified from E. coli.
Clone 3D6
Isotype IgG2a
Purification Protein-G Affinity Chromatography
Alternative Name BHMT (BHMT Antibody Abstract)
Background Betaine homocysteine methyltransferase (BHMT), a cytosolic enzyme, and its partial fragments were discovered as autolysosomal membrane proteins from rat liver in the presence of leupeptin. BHMT was also found in human liver. BHMT transfers a methyl group from betaine to homocysteine to form DMG (dimethylglycine) and Met. In vivo, liver BHMT expression is influenced by dietary changes in sulphur amino acids, choline and betaine.Synonyms: BHMT, BHMT (Betaine-homocysteine methyltransferase), BHMT1, Betaine homocysteine S methyltransferase, Betaine homocysteine S methyltransferase 1, Betaine--homocysteine S-methyltransferase 1, Betaine-homocysteine methyltransferase Betaine homocysteine methyltransferase, EC 2.1.1.5
Gene ID 635
UniProt C6KNH7
Research Area Signaling, Metabolism, Amino Acids, Enzymes
Pathways Methionine Biosynthetic Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate-Buffered Saline ( pH 7.4), 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Betaine--Homocysteine S-Methyltransferase (BHMT) (AA 1-406), (N-Term) antibody (ABIN1105529) anti-Betaine--Homocysteine S-Methyltransferase (BHMT) (AA 1-406), (N-Term) antibody
Background publications Sparks, Collins, Chirieac, Cianci, Jokinen, Sowden, Galloway, Sparks: "Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase." in: The Biochemical journal, Vol. 395, Issue 2, pp. 363-71, 2006 (PubMed).

Garrido, Gasset, Sanz-Aparicio, Alfonso, Pajares: "Rat liver betaine-homocysteine S-methyltransferase equilibrium unfolding: insights into intermediate structure through tryptophan substitutions." in: The Biochemical journal, Vol. 391, Issue Pt 3, pp. 589-99, 2005 (PubMed).

Miller, Szegedi, Garrow: "Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro." in: The Biochemical journal, Vol. 392, Issue Pt 3, pp. 443-8, 2005 (PubMed).

Zhu, Curry, Wen, Wicker, Shaw, Lammer, Yang, Jafarov, Finnell: "Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts?" in: American journal of medical genetics. Part A, Vol. 135, Issue 3, pp. 274-7, 2005 (PubMed).

Weisberg, Park, Ballman, Berger, Nunn, Suh, Breksa, Garrow, Rozen: "Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease." in: Atherosclerosis, Vol. 167, Issue 2, pp. 205-14, 2003 (PubMed).

McKeever, Weir, Molloy, Scott: "Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat." in: Clinical science (London, England : 1979), Vol. 81, Issue 4, pp. 551-6, 1991 (PubMed).

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