C1S antibody (Complement Component 1, S Subcomponent)

Details for Product anti-C1S Antibody No. ABIN1105612, Supplier: Log in to see
Antigen
  • C1S
  • r-gsp
  • AA959438
  • AI255193
  • AI327365
  • C1sa
  • complement component 1, s subcomponent
  • C1S
  • c1s
  • LOC100222051
  • C1s
Alternatives
anti-Human C1S antibody for ELISA
Reactivity
Human
80
21
21
3
1
Host
Mouse
46
30
4
Clonality (Clone)
Monoclonal ()
Conjugate
This C1S antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
50
26
24
13
13
11
7
5
3
3
2
2
2
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Clone M81
Isotype IgG1
Specificity Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. It blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Alternative Name C1s (C1S Antibody Abstract)
Background Activated C1s is a glycosylated single-polypeptide zymogen, MW 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a.Synonyms: C1 esterase, Complement 1s, Complement C1s, Complement C1s subcomponent, Complement component 1 subcomponent s
Gene ID 716
NCBI Accession NP_001725
UniProt P09871
Research Area Immunology, Innate Immunity, Complement Factors
Pathways Complement System
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % bovine serum albumin
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Nakagawa, Sakiyama, Tsuchida, Yamaguchi, Toyoguchi, Masuda, Moriya: "Complement C1s activation in degenerating articular cartilage of rheumatoid arthritis patients: immunohistochemical studies with an active form specific antibody." in: Annals of the rheumatic diseases, Vol. 58, Issue 3, pp. 175-81, 1999 (PubMed).

Matsumoto, Nagaki, Kitamura, Kuramitsu, Nagasawa, Seya: "Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 8, pp. 2743-50, 1989 (PubMed).

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