IL6ST antibody (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor))

Details for Product anti-IL6ST Antibody No. ABIN1105846, Supplier: Log in to see
Antigen
  • CD130
  • CDW130
  • GP130
  • IL-6RB
  • 5133400A03Rik
  • AA389424
  • BB405851
  • D13Ertd699e
  • gp130
  • Ac1055
  • Gp130
  • Il-6rb
  • NCR
  • interleukin 6 signal transducer (gp130, oncostatin M receptor)
  • interleukin 6 signal transducer
  • neutrophil migration
  • IL6ST
  • Il6st
  • il6st
  • LOC100349330
  • NM
Alternatives
anti-Human IL6ST antibody for Enzyme Immunoassay
Reactivity
Human
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Host
Mouse
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Clonality (Clone)
Monoclonal ()
Conjugate
This IL6ST antibody is un-conjugated
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Application
Functional Studies (Func), Flow Cytometry (FACS)
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Options
Supplier
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Supplier Product No.
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Immunogen Natural soluble gp130. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
Clone B-P8
Isotype IgG1
Specificity Recognizes the soluble antigen. Recognizes the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ion Exchange Chromatography.
Sterility 0.22 μm filtered
Alternative Name CD130 / IL6ST (IL6ST Antibody Abstract)
Background IL-6 activates intracellular signaling through binding a receptor consisting of an 80 kDa ligand-binding protein (IL-6R) and a second protein of 130 kDa. IL-6 first binds to IL-6R which subsequently associates with a gp130 dimer. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6R is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-tocell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
Gene ID 3572
NCBI Accession NP_002175
UniProt P40189
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways JAK-STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 μm and treated to remove Endotoxins.
Preservative Without preservative
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody (ABIN1105846) anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody
Background publications Giese, Au-Yeung, Herrmann, Diefenbach, Haan, Küster, Wortmann, Roderburg, Heinrich, Behrmann, Müller-Newen: "Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 39205-13, 2003 (PubMed).

Timmermann, Küster, Kurth, Heinrich, Müller-Newen: "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor." in: European journal of biochemistry / FEBS, Vol. 269, Issue 11, pp. 2716-26, 2002 (PubMed).

Aoki, Narazaki, Kishimoto, Tosato: "Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus." in: Blood, Vol. 98, Issue 10, pp. 3042-9, 2001 (PubMed).

Kurth, Horsten, Pflanz, Timmermann, Küster, Dahmen, Tacken, Heinrich, Müller-Newen: "Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 1, pp. 273-82, 2000 (PubMed).

Olivier, Auguste, Chabbert, Lelièvre, Chevalier, Gascan: "Identification of a gp130 cytokine receptor critical site involved in oncostatin M response." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5648-56, 2000 (PubMed).

Rebouissou, Wijdenes, Autissier, Tarte, Costes, Liautard, Rossi, Brochier, Klein: "A gp130 interleukin-6 transducer-dependent SCID model of human multiple myeloma." in: Blood, Vol. 91, Issue 12, pp. 4727-37, 1998 (PubMed).

Horsten, Müller-Newen, Gerhartz, Wollmer, Wijdenes, Heinrich, Grötzinger: "Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex." in: The Journal of biological chemistry, Vol. 272, Issue 38, pp. 23748-57, 1997 (PubMed).

Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." in: FEBS letters, Vol. 407, Issue 2, pp. 141-7, 1997 (PubMed).

Simpson, Hammacher, Smith, Matthews, Ward: "Interleukin-6: structure-function relationships." in: Protein science : a publication of the Protein Society, Vol. 6, Issue 5, pp. 929-55, 1997 (PubMed).

Chevalier, Fourcin, Robledo, Wijdenes, Pouplard-Barthelaix, Gascan: "Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14764-72, 1996 (PubMed).

Gu, Wijdenes, Zhang, Hallet, Clement, Klein: "Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M." in: Journal of immunological methods, Vol. 190, Issue 1, pp. 21-7, 1996 (PubMed).

Wijdenes, Heinrich, Müller-Newen, Roche, Gu, Clément, Klein: "Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies." in: European journal of immunology, Vol. 25, Issue 12, pp. 3474-81, 1996 (PubMed).

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