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PD-L1 antibody (CD274 Molecule) (Biotin)

Details for Product anti-CD274 Antibody No. ABIN1106178, Supplier: Login to see New
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(194), (94), (21), (1), (1)
(96), (90), (60), (20), (2)
Clonality (Clone)
Monoclonal ()
This PD-L1 antibody is conjugated to Biotin
(23), (19), (19), (13), (6), (3), (3), (3), (2), (2), (2), (1), (1)
Flow Cytometry (FACS)
(127), (117), (81), (44), (16), (16), (15), (8), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Pubmed 2 references available
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Quantity 50 tests
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Full-length human PD-L1 transfected L cells
Clone MIH3
Isotype IgG1
Specificity This antibody reacts with human CD274.
Purification Protein A agarose
Alternative Name CD274 / PDL1 (CD274 Antibody Abstract)
Background Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunoglobulin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-γ, GM-CSF and IL-10 from the T cells were enhanced.Synonyms: B7 homolog 1, B7H1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, Programmed death ligand 1
Gene ID 29126
NCBI Accession NP_054862
UniProt Q9NZQ7
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.02 mg/mL
Buffer PBS, 0.09 % NaN3, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 2 - 8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-PD-L1 antibody (CD274 Molecule)  (Biotin) (ABIN1106178) anti-CD274 Molecule (CD274) antibody (Biotin)
Background publications del Rio, Rodriguez-Barbosa, Kremmer et al.: "CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 11, pp. 6861-6, 2007 (PubMed).

Yamazaki, Akiba, Iwai et al.: "Expression of programmed death 1 ligands by murine T cells and APC." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5538-45, 2002 (PubMed).

Catalog No. ABIN1106178
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