CD274 Molecule (CD274) antibody (Biotin)

Details for Product No. ABIN1106178
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Antigen
Synonyms A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, RGD1566211
Reactivity
Human
(110), (105), (50), (20), (20)
Host
Mouse
(93), (41), (36), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(17), (13), (11), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(92), (67), (50), (30), (21), (21), (15), (7), (5), (4), (2), (2), (1)
Pubmed 2 references available
Quantity 50 tests
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1106178
357.50 $
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Immunogen Full-length human PD-L1 transfected L cells
Clone MIH3
Isotype IgG1
Specificity This antibody reacts with human CD274.
Purification Protein A agarose
Alternative Name CD274 / PDL1
Background Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunoglobulin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-gamma, GM-CSF and IL-10 from the T cells were enhanced.
Alternate names: B7 homolog 1, B7H1, B7H1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, Programmed cell death 1 ligand 1, Programmed death ligand 1
Gene ID 29126
NCBI Accession NP_054862
UniProt Q9NZQ7
Restrictions For Research Use only
Format Liquid
Concentration 0.02 mg/mL
Buffer PBS, 0.09% Sodium azide, 1% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 2 - 8 °C.
Expiry Date 12 months
Supplier Images
anti-CD274 Molecule (CD274) antibody (Biotin) anti-CD274 Molecule (CD274) antibody (Biotin)
Background publications Yamazaki, Akiba, Iwai et al.: "Expression of programmed death 1 ligands by murine T cells and APC." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5538-45, 2002 (PubMed).

del Rio, Rodriguez-Barbosa, Kremmer et al.: "CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 11, pp. 6861-6, 2007 (PubMed).

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