CD48 Molecule (CD48) antibody

Details for Product No. ABIN1106420
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Antigen
Synonyms AI449234, AW610730, BCM1, BLAST, BLAST-1, BLAST1, Bcm-1, MEM-102, SLAMF2, Sgp-60, hCD48, mCD48
Reactivity
Human
(108), (91), (43), (12), (12), (5), (3), (3), (1)
Host
Mouse
(98), (58), (33), (26), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(34), (25), (16), (12), (8), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(154), (53), (39), (23), (18), (10), (8), (5), (5), (4), (3), (3)
Pubmed 3 references available
Quantity 0.2 mg
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Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1106420
467.50 $
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Clone MEM-102
Isotype IgG1
Specificity This antibody recognises to the 45kD leucocyte surface glycoprotein specific for the CD48 antigen which is closely related to the activation antigen, Blast-1. It is useful in the detection of CD48 positive cells and may be used in studies to differentiate haemapoietic tumours, sarcomas and melanomas.
Purification Affinity chromatography on Protein G
Alternative Name CD48
Background CD48 is a glycosyl phophatidyl inositol (GPI) anchored cell surface protein also known as Blast1, HuLy m3, BCM1 (in mouse), and OX45 (in rat). CD48 is strongly expressed on lymphocytes and monocytes and weakly on granulocytes but is absent on platelets, fibrolasts, epithelium and endothelium. CD48 is one of the markers for detecting the defects of GPI anchoring structure on patients with paroxysmal nocturnal hemoglobulinuria (PNH) and serves as a low affinity ligand for CD2. The CD48 antigen is closely related to the activation antigen, Blast 1.
Alternate names: B-lymphocyte activation marker BLAST-1, BCM1, BCM1 surface antigen, BLAST1, Leukocyte antigen MEM-102, MEM-102, TCT.1
Gene ID 962
NCBI Accession NP_001769
UniProt P09326
Research Area CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH7.4 containing 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody undiluted at -20°C.
Expiry Date 12 months
Background publications Cinek, Horejsí: "The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 7, pp. 2262-70, 1992 (PubMed).

Korínek, Stefanová, Angelisová et al.: "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1." in: Immunogenetics, Vol. 33, Issue 2, pp. 108-12, 1991 (PubMed).

Staffler, Szekeres, Schütz et al.: "Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 4, pp. 1707-14, 2003 (PubMed).

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