Complement Factor B antibody (CFB)

Details for Product anti-CFB Antibody No. ABIN1106810, Supplier: Log in to see
Antigen
  • bf
  • Bf-1
  • Brre-Bf
  • zgc:114032
  • Bf
  • Sp152
  • bfb-A
  • Bf B
  • LOC397725
  • fc04c04
  • wu:fc04c04
  • bf/c2
  • CFB
  • AHUS4
  • BF
  • BFD
  • CFAB
  • FB
  • FBI12
  • GBG
  • H2-Bf
  • PBF2
  • AI195813
  • AI255840
  • B
  • C2
  • Fb
  • Da1-24
  • complement factor B
  • zgc:158446
  • ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
  • complement factor B-like
  • CFB
  • cfb
  • Bf
  • bfb-A
  • LOC397725
  • zgc:158446
  • bf/c2
  • Atp5s
  • Cfb
  • LOC100355944
Alternatives
anti-Human Complement Factor B antibody for ELISA
Reactivity
Human
179
50
47
2
1
1
1
1
1
Host
Mouse
131
56
16
7
Clonality (Clone)
Monoclonal ()
Conjugate
This Complement Factor B antibody is un-conjugated
22
17
9
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
140
124
54
30
25
19
16
13
12
12
9
6
6
5
4
3
2
1
1
Options
Supplier
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Clone P21-15
Isotype IgG2a
Specificity This antibody detects Complement factor B/Ba.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Alternative Name Complement Factor B (CFB Antibody Abstract)
Background Factor B is an acute-phase protein. Levels of factor B increase during inflammation. Complement factor B is a single- chain molecule of 764 amino acids (MW 90 kD), including a leader peptide of 25 amino acids. Factor B provides the catalytic subunit of the C3/C5 convertases of the alternative complement pathway. Assembly of the C3 convertase (C3bBb) requires binding of factor B to C3b (C3.H2O) and factor D-mediated cleavage of bound factor B resulting in the release of Ba (MW 33 kD). The C3 convertase is stabilized by the binding of properdin. This provides a positive amplification loop for the classical and alternative complement pathways. Bb (MW 60 kD) is the serine protease element of this convertase. After cleavage of C3, the C5 convertase ((C3b)2Bb) is formed. The Bb fragment may be regarded as a better indicator of the alternative pathway of complement activation than Ba as impaired renal filtration does directly influence Ba levels. Whereas Bb is elevated 2.2-fold in chronic renal failure (CRF) patients, plasma concentrations of Ba are 8.4-fold higher in CRF and 16-fold higher in end-stage renal disease (ESRD) patients compared to normals.In addition to complement activation, factor B fragments participate in other immunological functions.Synonyms: BF, BFD, C3/C5 convertase, CFB, Glycine-rich beta glycoprotein, PBF2, Properdin factor B
Gene ID 629
NCBI Accession NP_001701
UniProt P00751
Research Area Coagulation
Pathways Complement System, Proton Transport, Ribonucleoside Biosynthetic Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Oppermann, Kurts, Zierz, Quentin, Weber, Götze: "Elevated plasma levels of the immunosuppressive complement fragment Ba in renal failure." in: Kidney international, Vol. 40, Issue 5, pp. 939-47, 1992 (PubMed).

Oppermann, Baumgarten, Brandt, Gottsleben, Kurts, Götze: "Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays." in: Journal of immunological methods, Vol. 133, Issue 2, pp. 181-90, 1990 (PubMed).

Oppermann, Haubitz, Quentin, Götze: "Complement activation in patients with renal failure as detected through the quantitation of fragments of the complement proteins C3, C5, and factor B." in: Klinische Wochenschrift, Vol. 66, Issue 18, pp. 857-64, 1988 (PubMed).