Keratin 10 (KRT10) antibody

Details for Product No. ABIN1106898
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Antigen
Synonyms KRT10, KRT9, BCIE, BIE, CK10, EHK, K10, KPP, Ka10, Ker10, D130054E02Rik, K1C1, Krt-1.10, Krt1-10
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
(153), (52), (45), (28), (25), (24), (12), (7), (2), (1)
Host
Mouse
(88), (67), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Flow Cytometry (FACS)
(97), (70), (37), (33), (31), (30), (30), (20), (16), (7), (3)
Pubmed 7 references available
Quantity 0.1 mg
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Catalog No. ABIN1106898
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Immunogen Cytokeratins from the Human epidermis
Clone RKSE60
Isotype IgG1
Specificity RKSE60 reacts exclusively with Cytokeratin 10 which is present in keratinizing stratified epithelia and in differentiated areas of highly differentiated squamous cell carcinomas.
Purification Purified
Alternative Name Cytokeratin 10
Background Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Alternate names: CK-10, CK10, Cytokeratin-10, K10, KPP, KRT10, Keratin, Keratin-10, Type I Cytoskeletal 10
Gene ID 3858
NCBI Accession NP_000412
UniProt P13645
Research Area Signaling, Cytoskeleton, Cytokeratins, Extracellular Matrix
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store lyophilized (preferably in a desiccator) at 2-8°C and reconstituted (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Schaafsma, Ramaekers, van Muijen et al.: "Distribution of cytokeratin polypeptides in human transitional cell carcinomas, with special emphasis on changing expression patterns during tumor progression." in: The American journal of pathology, Vol. 136, Issue 2, pp. 329-43, 1990 (PubMed).

Ramaekers, van Niekerk, Poels et al.: "Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas." in: The American journal of pathology, Vol. 136, Issue 3, pp. 641-55, 1990 (PubMed).

Smedts, Ramaekers, Robben et al.: "Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia." in: The American journal of pathology, Vol. 136, Issue 3, pp. 657-68, 1990 (PubMed).

Puts, Moesker, Kenemans et al.: "Expression of cytokeratins in early neoplastic epithelial lesions of the uterine cervix." in: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, Vol. 4, Issue 4, pp. 300-13, 1986 (PubMed).

Broers, Carney, Klein Rot et al.: "Intermediate filament proteins in classic and variant types of small cell lung carcinoma cell lines: a biochemical and immunochemical analysis using a panel of monoclonal and polyclonal antibodies." in: Journal of cell science, Vol. 83, Issue 12, pp. 37-60, 1987 (PubMed).

Ramaekers, Huysmans, Schaart et al.: "Tissue distribution of keratin 7 as monitored by a monoclonal antibody." in: Experimental cell research, Vol. 170, Issue 1, pp. 235-49, 1987 (PubMed).

Odin, Obrink: "Quantitative determination of the organ distribution of the cell adhesion molecule cell-CAM 105 by radioimmunoassay." in: Experimental cell research, Vol. 171, Issue 1, pp. 1-15, 1987 (PubMed).

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