Keratin 13 (KRT13) antibody

Details for Product No. ABIN1106901
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Antigen
Synonyms krt13, CK13, K13, Ka13, Krt-1.13, Krt1-13, ck13, k13
Reactivity
Human, Zebrafish (Danio rerio)
(104), (27), (26), (16), (12), (3), (3), (2), (1), (1), (1)
Host
Mouse
(54), (45), (8), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(83), (50), (27), (25), (24), (23), (15), (10), (8), (4), (1)
Pubmed 8 references available
Quantity 0.1 mg
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Catalog No. ABIN1106901
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Immunogen Cytokeratin preparation from Human esophagus.
Clone 1C7
Isotype IgG2a
Specificity 1C7 reacts exclusively with Cytokeratin 13 which is present in non-cornified squamous epithelia, except cornea, and transitional epithelial regions, with the exception of basal cell layers of some stratified epithelia. Species Reactivity: Tested: Human, Zebrafish.
Purification Purified
Alternative Name Cytokeratin 13
Background Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Alternate names: CK-13, CK13, K13, KRT-13, KRT13, Keratin type I cytoskeletal 13, Keratin-13
Gene ID 3860
NCBI Accession NP_002265
UniProt P13646
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 10 mM (0.065%) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the lyophilized antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Reconstituted can be aliquotted and stored at -20°C to -70°C.
Expiry Date 12 months
Background publications Bauwens, De Groot, Ramaekers et al.: "Expression of intermediate filament proteins in the adult human vestibular labyrinth." in: The Annals of otology, rhinology, and laryngology, Vol. 101, Issue 6, pp. 479-86, 1992 (PubMed).

Smedts, Ramaekers, Troyanovsky et al.: "Keratin expression in cervical cancer." in: The American journal of pathology, Vol. 141, Issue 2, pp. 497-511, 1992 (PubMed).

Smedts, Ramaekers, Robben et al.: "Changing patterns of keratin expression during progression of cervical intraepithelial neoplasia." in: The American journal of pathology, Vol. 136, Issue 3, pp. 657-68, 1990 (PubMed).

van Niekerk, Boerman, Ramaekers et al.: "Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas." in: The American journal of pathology, Vol. 138, Issue 2, pp. 455-63, 1991 (PubMed).

van Muijen, Ruiter, Franke et al.: "Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. 4 and 13." in: Experimental cell research, Vol. 162, Issue 1, pp. 97-113, 1986 (PubMed).

Weikel, Wagner, Moll: "Characterization of subcolumnar reserve cells and other epithelia of human uterine cervix. Demonstration of diverse cytokeratin polypeptides in reserve cells." in: Virchows Archiv. B, Cell pathology including molecular pathology, Vol. 54, Issue 2, pp. 98-110, 1988 (PubMed).

Van Niekerk, Ramaekers, Hanselaar et al.: "Changes in expression of differentiation markers between normal ovarian cells and derived tumors." in: The American journal of pathology, Vol. 142, Issue 1, pp. 157-77, 1993 (PubMed).

van Dorst, van Muijen, Litvinov et al.: "The limited difference between keratin patterns of squamous cell carcinomas and adenocarcinomas is explicable by both cell lineage and state of differentiation of tumour cells." in: Journal of clinical pathology, Vol. 51, Issue 9, pp. 679-84, 1999 (PubMed).

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