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GFAP antibody (Glial Fibrillary Acidic Protein)

Details for Product anti-GFAP Antibody No. ABIN1107345, Supplier: Log in to see
Antigen
  • GFAP
  • AI836096
  • cb345
  • etID36982.3
  • gfapl
  • wu:fb34h11
  • wu:fk42c12
  • xx:af506734
  • zgc:110485
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Mouse
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Clonality (Clone)
Monoclonal ()
Conjugate
This GFAP antibody is un-conjugated
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Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Supplier
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Immunogen GFAP from pig spinal cord.
Clone GA-8
Isotype IgG1
Specificity This antibody reacts to GFAP.
Purification Affinity chromatography
Alternative Name GFAP (GFAP Antibody Abstract)
Background GGlial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. GFAP has been located in rat kidney glomeruli and peritubular fibroblasts, leydig cells of testis, skin keratinocytes, osteocytes of bones, chondrocytes of epiglottis, bronchus, and stellate-shaped cells of the pancreas and liver. Its expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination. GFAP has also been shown to play a role in mitosis by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow.Synonyms: Glial Fibrillary Acidic Protein
Gene ID 2670
NCBI Accession NP_001124491
UniProt P14136
Research Area Stem Cells, Cytoskeleton, Glia marker, Cell/Tissue Markers, Neurology
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Restore with 1.2 % sodium acetate or neutral PBS
Concentration 0,1 mg/mL
Buffer 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-GFAP antibody (Glial Fibrillary Acidic Protein) (ABIN1107345) anti-Glial Fibrillary Acidic Protein (GFAP) antibody
Western Blotting (WB) image for anti-GFAP antibody (Glial Fibrillary Acidic Protein) (ABIN1107345) anti-Glial Fibrillary Acidic Protein (GFAP) antibody (Image 2)
Background publications Rodriguez, Gauthier, Bertini et al.: "Infantile Alexander disease: spectrum of GFAP mutations and genotype-phenotype correlation." in: American journal of human genetics, Vol. 69, Issue 5, pp. 1134-40, 2001 (PubMed).

Brenner, Johnson, Boespflug-Tanguy et al.: "Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease." in: Nature genetics, Vol. 27, Issue 1, pp. 117-20, 2001 (PubMed).