Inhibin alpha antibody

Catalog No. ABIN1107757

Product Details anti-Inhibin alpha Antibody

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Inhibin alpha antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Recognizes INHA (A-Inhibin subunit precursor, inhibin alpha subunit ).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Purified

Clone: 4A2

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, 0.03 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Inhibin alpha

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Alternative Name: Inhibin alpha / INHA (INHA Products)

Synonyms: si:dkey-91f15.2 antibody, INHA antibody, MGC108500 antibody, AW555078 antibody, inhibin, alpha antibody, inhibin alpha subunit antibody, inhibin alpha antibody, inhibin alpha L homeolog antibody, inha antibody, INHA antibody, inha.L antibody, Inha antibody

Background: INHA (A-inhibin subunit precursor, inhibin alpha subunit ), also called inhibin (alpha), which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.

Gene ID: 3623

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion