MFN2 antibody (N-Term)

Catalog No. ABIN1108249

Product Details anti-MFN2 Antibody

Target: MFN2 (Mitofusin 2 (MFN2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MFN2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects Mitofusin-2 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogen: Synthetic peptide corresponding to a sequence mapping at the N-terminal of human MFN2 .Remarks: Sequence is different from the related rat and mouse sequence by single amino acids.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

Preservative: Sodium azide, Thimerosal (Merthiolate)

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Alternative Name: Mitofusin-2 (MFN2 Products)

Synonyms: CG3869 antibody, Dmel\\CG3869 antibody, MARF antibody, Marf-1 antibody, Mfn antibody, anon-WO0125274.3 antibody, dMFN antibody, dMfn antibody, dmfn antibody, marf antibody, mfn antibody, mfn2 antibody, MFN2 antibody, hsg antibody, cmt2a antibody, cprp1 antibody, cmt2a2 antibody, CMT2A antibody, CMT2A2 antibody, CPRP1 antibody, HSG antibody, D630023P19Rik antibody, Fzo antibody, mg:cb01g09 antibody, si:dkeyp-104h9.2 antibody, wu:fb79a11 antibody, mitofusin 2 antibody, Mitochondrial assembly regulatory factor antibody, mitofusin-2 antibody, mitofusin 2 L homeolog antibody, MFN2 antibody, Marf antibody, mfn2 antibody, LOC100186475 antibody, Mfn2 antibody, mfn2.L antibody

Background: Mitofusin 2 (MFN2) is a mitochondrial transmembrane GTPase regulating mitochondrial fusion and that the nucleotide-dependent activation of MFN2 concomitantly protects the organelle from permeability transition. It is mapped to chromosome 1 and encodes a 757-amino acid protein that contains an ATP/GTP-binding site motif. It is expressed in many tissues and cell lines such as brain and KG-1 with the highest expression in heart and skeletal muscle. This protein contains an N-terminal GTPase domain and a transmembrane domain near the C terminus. It shares 60 % identity with MFN1. When stably expressed in COS-7 cells, MFN2 colocalizes with mitochondrial markers. Axonal CMT type 2A and autosomal dominant HMSN VI are caused by MFN2 and mutations in MFN2, which emphasizes its important role of mitochondrial function for both optic atrophies and peripheral neuropathies.Synonyms: CPRP1, Charcot-Marie-Tooth disease, KIAA0214, MFN2

Gene ID: 9927

NCBI Accession: NP_001121132

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development