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Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) (C-Term) antibody

Details for Product No. ABIN1108490, Supplier: Log in to see
Antigen
  • AA209988
  • AI551208
  • CAR
  • CAR-beta
  • Care2
  • ESTM32
  • MB67
  • CAR1
  • CXR
  • constitutive androstane receptor
  • nuclear receptor subfamily 1, group I, member 3
  • CAR
  • LOC100346291
  • Nr1i3
  • NR1I3
Alternatives
anti-Mouse (Murine) Nuclear Receptor Subfamily 1, Group I, Member 3 antibody for Immunohistochemistry
Epitope
C-Term
15
14
13
11
9
6
4
3
3
2
2
2
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
103
26
19
7
4
4
4
2
2
1
1
1
1
Host
Rabbit
92
20
Clonality
Polyclonal
Conjugate
Un-conjugated
6
5
5
2
2
2
Application
Western Blotting (WB)
105
49
29
14
5
5
2
2
1
1
1
1
1
1
Options
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Immunogen The immunogen for anti-NR1I3 antibody: synthetic peptide directed towards the C terminal of human NR1I3.
Sequence FHGTLRKLQL QEPEYVLLAA MALFSPDRPG VTQRDEIDQL QEEMALTLQS
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Pig, DogSpecies reactivity (tested):Human
Purification Purified using Protein A affinity column
Alternative Name NR1I3 / CAR (NR1I3 Antibody Abstract)
Background NR1I3 is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members.Synonyms: Constitutive activator of retinoid response, Constitutive androstane receptor, MB67, Nuclear receptor subfamily 1, Orphan nuclear receptor MB67, group I, member 3
Gene ID 9970
NCBI Accession NP_005113
Pathways Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Add 100 μL of distilled water to a final concentration of 1 mg/mL.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
Supplier Images
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) (C-Term) antibody (ABIN1108490) Human HepG2; WB Suggested Anti-NR1I3 Antibody Titration: 1.25ug/ml. Positive Control:...
Background publications Ferguson, Chen, LeCluyse, Negishi, Goldstein: "Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha." in: Molecular pharmacology, Vol. 68, Issue 3, pp. 747-57, 2005 (PubMed).