EMAPII is an approximate 20 kDa apoptosis-induced pro-inflammatory cytokine, produced by enzymatic cleavage of a precursor identical to the p43 auxiliary component of the aminoacyl-tRNA synthetase complex.Studies have shown the ability of EMAPII to induce monocyte and neutrophil chemotaxis, stimulate tissue factor-dependent coaggulation, elevate the expression of E- and P-selectins and tumour necrosis factor receptor-1, induce stress-related apoptosis in endothelial cells, inhibit angiogenesis of vascular beds, and suppress primary and metastatic tumour growth.Synonyms: AIMP1, Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, EMAP-2, EMAP-II, Endothelial monocyte-activating polypeptide 2, Endothelial monocyte-activating polypeptide II, Multisynthase complex auxiliary component p43, Small inducible cytokine subfamily E member 1