CD44 antibody (APC)

Catalog No. ABIN1112149

Product Details anti-CD44 Antibody (APC)

Target: CD44

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This CD44 antibody is conjugated to APC

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Immunogen: Peripheral Blood Mononuclear cells Positive control: Peripheral Blood from a healthy donor.

Clone: HI44a

Isotype: IgG1

Application Details

Application Notes: It is recommended for use in flow cytometry. This reagent is effective for direct immunofluorescence staining of human tissue for flow cytometric analysis using 20 µl/10^6 cells.

Comment:

Allophycocyanin (Febico, Far East Bio-Tech Co.).

Restrictions: For Research Use only

Handling

Storage: 4 °C

Target Details for CD44

Target: CD44

Alternative Name: CD44 (CD44 Products)

Synonyms: CDW44 antibody, CSPG8 antibody, ECMR-III antibody, HCELL antibody, HUTCH-I antibody, IN antibody, LHR antibody, MC56 antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody, Pgp1 antibody, AU023126 antibody, AW121933 antibody, AW146109 antibody, HERMES antibody, Ly-24 antibody, Pgp-1 antibody, CD44A antibody, METAA antibody, RHAMM antibody, XCD44 antibody, cd44 antibody, cdw44 antibody, cspg8 antibody, ecmr-iii antibody, hcell antibody, lhr antibody, mc56 antibody, mdu2 antibody, mdu3 antibody, mic4 antibody, mutch-i antibody, pgp1 antibody, CD44 molecule (Indian blood group) antibody, syndecan 4 antibody, CD44 antigen antibody, CD44 molecule (Indian blood group) S homeolog antibody, CD44 antibody, SDC4 antibody, Cd44 antibody, cd44.S antibody

Background: The mature CD44 antigen is a transmembranous molecule which has undergone both extensive O-linked and N-linked glycosylation. The main cellular reactivity is on leucocytes and red blood cells with only weak reactivity on platelets. CD44 antigen is widely expressed on most cell types including leukocytes, erythrocytes, endothelial cells and epithelial cells, but not on platelets. CD44 is involved in leukocyte attaching and rolling on endothelial cells, homing to peripheral lymphoid organs and sites of inflammation, and leukocyte aggregation. CD44 HI44a recognizes a cell-surface glycoprotein that exists in a variety of isoforms. It is synthesized as a molecule of Mr 37 kDa s (kDa). Upon glycosylation, it is converted to an 80- to 95-kDa form. Alternatively, a 180- to 200-kDa form results from the addition of chondroitin sulfate. The CD44 antigen is present on approximately 90% of lymphocytes, monocytes, and granulocytes and in lower amounts on thymocytes, fibroblasts, and erythrocytes. The antigen mediates a variety of functions, including leucocyte-endothelial cell binding and lymphocyte homing to cer-tain peripheral lymphoid microenvironments.

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling