APOC3
Reactivity: Human, Rat, Mouse
WB, ELISA, IHC, ICC, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Can be used to detect the existence of Apo CIII in plasma and lipoproteins, forimmunoassay and immunoblotting. Dilution for immunoblot and ELISA range: 8,000 to 30,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Reconstitution
Reconstitutein 0.5 mL distilled water.
Concentration
1.2 mg/mL
Buffer
10 mM PBS, 0.15 M NaCl, pH 7.2 with 0.02 % sodium azide as preservative.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL). Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. It inhibits lipoprotein lipase and hepatic lipase and it is thought to delay catabolism of triglyceride-rich particles. An increase in ap °C-III levels induces the development of hypertriglyceridemia.Synonyms: Apo-CIII, Ap °C-III, Ap °C3, Apolipoprotein C-III, Apolipoprotein C3