CXCL2 antibody (Chemokine (C-X-C Motif) Ligand 2) (Biotin)

Details for Product anti-CXCL2 Antibody No. ABIN116265, Supplier: Log in to see
Antigen
  • GRO3
  • MIP-2alpha
  • Mip-2
  • Scyb2
  • CINC-2a
  • GRO2
  • GROb
  • MGSA-b
  • MIP-2a
  • MIP2
  • MIP2A
  • SCYB2
  • Gro2
  • MIP-2
  • Mgsa-b
  • Mip2
  • Scyb
  • GROB
  • GROX
  • CDW2
  • GID7
  • chemokine (C-X-C motif) ligand 2
  • WD repeat domain 26
  • CXCL2
  • Cxcl2
  • WDR26
Alternatives
anti-Rat (Rattus) CXCL2 antibody for Immunoprecipitation
Reactivity
Mouse (Murine)
87
54
40
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1
Host
Rabbit
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18
15
15
Clonality
Polyclonal
Conjugate
This CXCL2 antibody is conjugated to Biotin
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8
8
6
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6
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
159
105
43
15
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Options
Supplier
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Supplier Product No.
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Immunogen Highly pure (>98%) recombinant Murine MIP- 2.
Specificity This antibody detects MIP-2.
Purification Affinity Chromatography employing immobilized mMIP-2 matrix
Alternative Name CXCL2 / MIP2A (CXCL2 Antibody Abstract)
Background GRO beta is a member of the CXC, or chemokine class. It contains the ELR domain immediately preceding the first cysteine residue near the amino terminus. Other chemokines in this group include IL8, GRO alpha/beta/gamma, mouse KC, ENA78, GCP2, PBP/CTAPIII/beta TG/NAP2. These chemokines act primarily on neutrophils as chemoattractants and activators, including neutrophil degradation with release of myloperoxidase and other enzymes. GRO beta was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. GRO beta is an approximately 8 kDa polypeptide of 73 amino acids. The precursor form of GRO beta consists of 100 amino acids. To generate the mature GRO beta, the precursor cleaves its amino terminal 27 amino acids. GRO beta shows 60 % amino acid homology to human GRO alpha and GRO gamma.Synonyms: C-X-C motif chemokine 2, GRO2, GROB, Gro-beta, Growth-regulated protein beta, MIP-2A, MIP2-alpha, Macrophage inflammatory protein 2-alpha, SCYB2
Gene ID 20310
NCBI Accession NP_033166
UniProt P10889
Pathways Cellular Response to Molecule of Bacterial Origin
Application Notes ELISA: To detect mMIP-2 by direct ELISA (using 100 μL/well antibody solution) this antibodycan be used at a concentration of 0.15 - 0.30 μg/mL. Used in conjunction with compatiblesecondary reagents, allows the detection of at least 0.2 ng/well of recombinant mMIP-2. Western Blot: To detect mMIP-2 by Western Blot analysis this antibody can be used at aconcentration of 0.1 - 0.2 μg/mL. Used in conjunction with compatible secondary reagentsthe detection limit for recombinant mMIP-2 is 1.5 - 3.0 ng/lane, under either reducing ornon-reducing conditions.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Centrifuge vial prior to opening. Restore in sterile PBS containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL.
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
Product cited in: Sterzenbach, Lee, Brenneke, von Goetz, Schauer, Fox, Suerbaum, Josenhans: "Inhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells." in: Infection and immunity, Vol. 75, Issue 6, pp. 2717-28, 2007 (PubMed).

Background publications Gonzalez-Rey, Chorny, Robledo, Delgado: "Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia." in: The Journal of experimental medicine, Vol. 203, Issue 3, pp. 563-71, 2006 (PubMed).

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