Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PDCD1LG2 antibody

PDCD1LG2 Reactivity: Mouse FACS Host: Rat Monoclonal TY25 unconjugated
Catalog No. ABIN1176961
  • Target See all PDCD1LG2 Antibodies
    PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
    Reactivity
    • 69
    • 23
    • 10
    • 3
    Mouse
    Host
    • 47
    • 25
    • 10
    • 1
    Rat
    Clonality
    • 45
    • 35
    • 1
    Monoclonal
    Conjugate
    • 48
    • 9
    • 7
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PDCD1LG2 antibody is un-conjugated
    Application
    • 48
    • 38
    • 36
    • 30
    • 15
    • 11
    • 9
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    Flow Cytometry (FACS)
    Brand
    BD Pharmingen™
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    Immunogen
    Mouse B7-DC
    Clone
    TY25
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product PDCD1LG2 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    Preservative
    Azide free
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Shin, Kennedy, Gorski, Tsuchiya, Koseki, Azuma, Yagita, Chen, Powell, Pardoll, Housseau: "Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor." in: The Journal of experimental medicine, Vol. 198, Issue 1, pp. 31-8, (2003) (PubMed).

    Nguyen, Radhakrishnan, Ciric, Tamada, Shin, Pardoll, Chen, Rodriguez, Pease: "Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells." in: The Journal of experimental medicine, Vol. 196, Issue 10, pp. 1393-8, (2002) (PubMed).

    Latchman, Wood, Chernova, Chaudhary, Borde, Chernova, Iwai, Long, Brown, Nunes, Greenfield, Bourque, Boussiotis, Carter, Carreno, Malenkovich, Nishimura, Okazaki, Honjo, Sharpe, Freeman: "PD-L2 is a second ligand for PD-1 and inhibits T cell activation." in: Nature immunology, Vol. 2, Issue 3, pp. 261-8, (2001) (PubMed).

  • Target
    PDCD1LG2 (Programmed Cell Death 1 Ligand 2 (PDCD1LG2))
    Alternative Name
    CD273 (PDCD1LG2 Products)
    Synonyms
    PDL2 antibody, B7DC antibody, Btdc antibody, CD273 antibody, PD-L2 antibody, PDCD1L2 antibody, bA574F11.2 antibody, B7-DC antibody, F730015O22Rik antibody, programmed cell death 1 ligand 2 antibody, PDCD1LG2 antibody, Pdcd1lg2 antibody
    Background
    The TY25 monoclonal antibody specifically binds to CD273, also known as B7-DC or PD-L2. CD273 is a 42-kDa type I membrane glycoprotein encoded by the Pdcd1lg2 gene of the B7 family of the Ig superfamily. Pdcd1lg2 mRNA is expressed selectively in dendritic cells (DC), liver, and a few transformed cell lines (hepatic, neuroblastoma, and myeloid), but not in lymphoid tissues or macrophages. The protein has not been detected on resting peripheral T and B lymphocytes, macrophages, or DC, but it is upregulated upon activation of T cells, macrophages, and DC by a variety of stimulatory factors. B7-DC's receptor, PD-1, contains an ITIM (Immunoreceptor Tyrosine-based Inhibitory Motif) on its intracytoplasmic region and is expressed on activated B and T lymphocytes, suggesting that B7-DC-PD-1 interaction may be involved in the negative regulation of immune responses. The second PD-1 ligand, B7-H1 (PD-L1), is also a member of the B7 family of the Ig superfamily. B7-DC may also participate in positive immunoregulation, or costimulation of T cells, through an additional receptor, which is not PD-1 and distinct from the alternate receptor for B7-H1. Moreover, B7-DC is the first B7 ligand that has been found to participate in bi-directional communication, ligation of B7-DC on DC stimulates those DC. The TY25 antibody blocks the binding of B7-DC to PD-1, but not to its alternate ligand.
    Synonyms: Pdcd1lg2, B7dc, B7-DC, PD-1 ligand 2, PD-L2, Btdc
You are here:
Support