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Cullin 5 antibody (CUL5) (AA 4-18)

Details for Product anti-CUL5 Antibody No. ABIN117951, Supplier: Login to see New
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cul5, wu:fd17d09, wu:fi20h12, xx:11fd17d09, zgc:66185, Xcullin5, CG1401, CUL5, Cul5, Cullin 5, Cullin5, Dmel\\CG1401, cul-5, vacm-1, vacm1, VACM-1, VACM1, 4921514I20Rik, 8430423K24Rik, AI852817, C0300 ... show more
cul5, wu:fd17d09, wu:fi20h12, xx:11fd17d09, zgc:66185, Xcullin5, CG1401, CUL5, Cul5, Cullin 5, Cullin5, Dmel\\CG1401, cul-5, vacm-1, vacm1, VACM-1, VACM1, 4921514I20Rik, 8430423K24Rik, AI852817, C030032G03Rik, C330021I08Rik, Cullin-5 show less
AA 4-18, N-Term
(11), (9), (6), (3), (2), (2), (2), (2), (1), (1), (1)
Human, Mouse (Murine)
(74), (41), (38), (3), (2), (1), (1), (1), (1)
(73), (1)
This Cullin 5 antibody is un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(38), (23), (22), (19), (16), (8), (7), (4), (3), (2), (1)
Pubmed 9 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to amino acids 4-18 of Human Cul5 (N-terminus) coupled coupled to KLH.
Sequence Human Cullin 5 (780 aa 90.9 kDa): 1 matsnllknk gslqfedkwd fmrpivlkll rqesvtkqqw fdlfsdvhav clwddkgpak 61 ihqalkedil efikqaqarv lshqddtall kayivewrkf ftqcdilpkp fcqleitlmg 121 kqgsnkksnv edsivrklml dtwnesifsn iknrlqdsam klvhaerlge afdsqlvigv 181 resyvnlcsn pedklqiyrd nfekayldst erfyrtqaps ylqqngvqny mkyadaklke 241 eekralryle trrecnsvea lmeccvnalv tsfketilae cqgmikrnet eklhlmfslm 301 dkvpngiepm lkdleehiis agladmvaaa etittdseky veqlltlfnr fsklvkeafq 361 ddprfltard kaykavvnda tifklelplk qkgvglktqp eskcpellan ycdmllrktp 421 lskkltseei eaklkevllv lkyvqnkdvf mryhkahltr rlildisads eieenmvewl 481 revgmpadyv nklarmfqdi kvsedlnqaf kemhknnkla lpadsvniki lnagawsrss 541 ekvfvslpte ledlipevee fykknhsgrk lhwhhlmsng iitfknevgq ydlevttfql 601 avlfawnqrp rekisfenlk latelpdael rrtlwslvaf pklkrqvlly epqvnspkdf 661 tegtlfsvnq efsliknakv qkrgkinlig rlqlttermr eeenegivql rilrtqeaii 721 qimkmrkkis naqlqtelve ilknmflpqk kmikeqiewl iehkyirrde sdintfiyma
Specificity This product is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. This product reacts with human Cullin 5. Cross reactivity is expected against mouse Cul5 based on a high degree of sequence homology. Cross reactivity with other human cullins may occur.
Purification Delipidation and defibrination.
Alternative Name Cullin-5 (CUL5 Antibody Abstract)
Background Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 5 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 5 seems to be involved proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. Cullin 5 may form a cell surface vasopressin receptor. Cullin 5 is part of a E3 ubiquitin ligase complex with elongin BC complex (TCEB1 and TCEB2), RBX1 and MUF1, complexes with elongin BC complex (TCEB1 and TCEB2), RXB1 and TCEB3 or SOCS1 or WSB1, elongin BC complex (TCEB1 and TCEB2), RBX1 and VHL, elongin BC complex (TCEB1 and TCEB2), RBX1, adenovirus type 5 E1B-55 kDa protein and adenovirus type 5 E4-orf6. Cullin 5 Interacts with RBX1 and RNF7.Synonyms: CUL-5, CUL5, VACM-1, VACM1, Vasopressin-activated calcium-mobilizing receptor
Gene ID 8065
NCBI Accession NP_003469
UniProt Q93034
Application Notes Western blot (1/500-1/1,000): This antibody reacts with human Cul5. An 90.9 kDa bandcorresponding to human Cul5 is detected, Most cell lines expressing Cul5 can be used as a
Restrictions For Research Use only
Format Liquid
Concentration 85.0 mg/mL (by Refractometry)
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for up to one month or in aliquots at -20 °C for longer.
Supplier Images
Image no. 1 for anti-Cullin 5 antibody (CUL5) (AA 4-18) (ABIN117951) Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifier...
Product cited in: Ng, Yu, Lai et al.: "Biliary Complications Associated with Selective Internal Radiation (SIR) Therapy for Unresectable Liver Malignancies." in: Digestive diseases and sciences, 2008 (PubMed).

Background publications Yu, Yu, Liu et al.: "Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex." in: Science (New York, N.Y.), Vol. 302, Issue 5647, pp. 1056-60, 2003 (PubMed).

Liu, Furukawa, Matsumoto et al.: "NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases." in: Molecular cell, Vol. 10, Issue 6, pp. 1511-8, 2002 (PubMed).

Querido, Blanchette, Yan et al.: "Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex." in: Genes & development, Vol. 15, Issue 23, pp. 3104-17, 2001 (PubMed).

Jentsch, Pyrowolakis: "Ubiquitin and its kin: how close are the family ties?" in: Trends in cell biology, Vol. 10, Issue 8, pp. 335-42, 2000 (PubMed).

Ohta, Michel, Schottelius et al.: "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity." in: Molecular cell, Vol. 3, Issue 4, pp. 535-41, 1999 (PubMed).

Michel, Xiong: "Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 9, Issue 6, pp. 435-49, 1998 (PubMed).

Mathias, Johnson, Winey et al.: "Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins." in: Molecular and cellular biology, Vol. 16, Issue 12, pp. 6634-43, 1997 (PubMed).

Kipreos, Lander, Wing et al.: "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family." in: Cell, Vol. 85, Issue 6, pp. 829-39, 1996 (PubMed).

Catalog No. ABIN117951
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