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Details for Product No. ABIN118659

Integrin, alpha 2b (Platelet Glycoprotein IIb of IIb/IIIa Complex, Antigen CD41) (ITGA2B) antibody

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Antigen
Synonyms BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, GpIIb, AI172977, alphaIIb
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS)
Pubmed 2 references available
Catalog no. ABIN118659
Quantity 0.1 mg
Price
242.00 $   Plus shipping costs $45.00
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Immunogen Human platelet plasma membrane. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Clone PM6-248
Isotype IgG1
Specificity This antibody recognises the CD41 cell surface antigen. It has not been established if clone PM6/248 recognises free CD41 or CD41 only when complexed with CD61. However, antibody binding is reduced in the presence of EDTA suggesting that the epitope recognised is dependent upon an intact CD41/61 complex.
Purification Affinity Chromatography on Protein G.
Alternative Name CD41 / ITGA2B
Background CD41 is a 140kD glycoprotein expressed by platelets and megakaryocytes. CD41 is also known as platelet glycoprotein IIb, and functions as a receptor for fibrinogen, fibronectin and vWF.
Alternate names: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb
NCBI Accession 9606
UniProt P08514
Application Notes Flow Cytometry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Hornby, Brown, Wilkinson et al.: "Activation of human platelets by exposure to a monoclonal antibody, PM6/248, to glycoprotein IIb-IIIa." in: British journal of haematology, Vol. 79, Issue 2, pp. 277-85, 1992 (PubMed).

Michelson, Page, Casey et al.: "An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan." in: The Journal of rheumatology, Vol. 21, Issue 12, pp. 2261-5, 1995 (PubMed).

Alternatives for antigen "Integrin, alpha 2b (Platelet Glycoprotein IIb of IIb/IIIa Complex, Antigen CD41) (ITGA2B)", type "Antibodies"
Hosts (194), (49), (24)
Reactivities (210), (65), (19), (12), (5), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (207), (45), (39), (26), (26), (22), (21), (12), (10), (10), (7), (5), (2), (1)
Conjugates (42), (28), (26), (8), (7), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (2), (1), (1)
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