Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA) antibody

Antigen: Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA)

Synonyms: HFSP, CTLA3, Hf, SE1, TSP1, Ctla3, TSP-1, Ctla-3, AW494114, gzmA, GZMA, MGC157236, MET1, LMET1

Clonality: Monoclonal (GA6)

Host: Mouse

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Catalog no.: ABIN119562

Additional Information

Alternative name: Granzyme A (GZMA)

Swiss-Prot: P12544

Immunogen: Recombinant Granzyme A. Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Isotype: IgG1  (Matching secondary antibodies)

Clone: GA6

Description: Ganzyma A is a 60kD disulphide-linked homodimeric protein expressed in cytoplasmic granules of cytotoxic lymphocytes. The biological function of Granzyme A is unclear. It would appear that the molecule may have a role in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.

Specificity: This antibody recognises Granzyme A.

Application Details

Application Notes: Immunohistochemistry on paraffin sections: 1/50 - 1/200, This product requires antigen retrieval using heat treatment prior to staining of paraffin sections, Sodium citrate buffer pH 6.0 is recommended for this purpose. Western blotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Buffer: TRIS buffered saline containing 0.09% Sodium Azide

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.

Research Area: Cell/Tissue Markers

Restrictions: For Research Use only