GZMA antibody

Catalog No. ABIN119562

The Mouse Monoclonal anti-GZMA antibody (Clone GA6) (ABIN119562) specifically detects GZMA in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for GZMA antibody (ABIN119562)

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GZMA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GA6

Product Details anti-GZMA Antibody

Specificity: This antibody recognises Granzyme A.

Purification: Affinity chromatography on Protein A

Immunogen: Recombinant Granzyme A. Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line.

Isotype: IgG1

Application Details

Application Notes: Immunohistochemistry on paraffin sections: 1/50 - 1/200, This product requires antigen retrieval using heat treatment prior to staining of paraffin sections, Sodium citrate buffer pH 6.0 is recommended for this purpose. Western blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: TRIS buffered saline containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GZMA

Target: GZMA (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3) (GZMA))

Alternative Name: Granzyme A (GZMA)

Background: Ganzyma A is a 60kD disulphide-linked homodimeric protein expressed in cytoplasmic granules of cytotoxic lymphocytes. The biological function of Granzyme A is unclear. It would appear that the molecule may have a role in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.Synonyms: CTL tryptase, CTLA3, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, H factor, HFSP, Hanukkah factor

Gene ID: 3001

NCBI Accession: NP_006135

UniProt: P12544

Pathways: Apoptosis