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Adiponectin (ADIPOQ ) (AA 15-244) antibody

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Antigen
Epitope
AA 15-244
54
46
28
13
12
11
11
10
7
6
6
6
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
471
158
112
30
15
4
4
3
1
1
Host
Mouse
371
229
16
10
4
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
65
28
24
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
412
364
107
69
44
34
33
31
29
14
11
9
8
2
2
2
2
1
1
1
1
1
1
Supplier
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Immunogen Recombinant human adiponectin (15-244 aa) purified from E. coli
Clone 1G12
Isotype IgG1
Specificity This antibody (1G12) has the specificity against globular domain of adiponectin.
Purification Protein-G affinity chromatography
Alternative Name Adiponectin
Background Human Adiponectin, also referred to as AdipoQ, Acrp30, apm-1 or GBP28, is a secreted protein expressed exclusively in differentiated adipocyte (adipokine). Adiponectin contains a modular structure comprising an N-terminal collagenous domain followed by a C-terminal globular domain (gAcrp30). Adiponectin plays a role in various physiological processes such as energy homeostasis and obesity. Plasma levels of adiponectin are reduced in obese humans, and decreased levels are associated with insulin resistance and hyperinsulinemia.Synonyms: 30 kDa adipocyte complement-related protein, ACDC, ACRP30, ADIPOQ, APM1, Adipocyte, Adipocyte complement-related 30 kDa protein, Adipose most abundant gene transcript 1 protein, C1q and collagen domain-containing protein, GBP28, Gelatin-binding protein
Gene ID 9370
UniProt Q15848
Research Area Cancer, Atherosclerosis, Metabolism, Hormones
Application Notes ELISA. Western blot (1:250 - 1:1,000), recommended starting dilution is 1:500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, containing 0.02 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Yamauchi, Kamon, Minokoshi, Ito, Waki, Uchida, Yamashita, Noda, Kita, Ueki, Eto, Akanuma, Froguel, Foufelle, Ferre, Carling, Kimura, Nagai, Kahn, Kadowaki: "Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase." in: Nature medicine, Vol. 8, Issue 11, pp. 1288-95, 2002 (PubMed).

Berg, Combs, Scherer: "ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism." in: Trends in endocrinology and metabolism: TEM, Vol. 13, Issue 2, pp. 84-9, 2002 (PubMed).

Berg, Combs, Du, Brownlee, Scherer: "The adipocyte-secreted protein Acrp30 enhances hepatic insulin action." in: Nature medicine, Vol. 7, Issue 8, pp. 947-53, 2001 (PubMed).

Maeda, Okubo, Shimomura, Funahashi, Matsuzawa, Matsubara: "cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)." in: Biochemical and biophysical research communications, Vol. 221, Issue 2, pp. 286-9, 1996 (PubMed).