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PARK7 antibody (Parkinson Protein 7) (AA 1-189)

Details for Product anti-PARK7 Antibody No. ABIN121180, Supplier: Log in to see
Antigen
  • dj1
  • zgc:103725
  • DJ-1
  • Dj1
  • DJ1
  • CAP1
  • SP22
  • parkinson disease (autosomal recessive, early onset) 7
  • Parkinson disease (autosomal recessive, early onset) 7
  • parkinson protein 7
  • park7
  • PARK7
  • Park7
Alternatives
anti-Human PARK7 antibody for Enzyme Immunoassay
Epitope
AA 1-189, N-Term
35
35
16
13
10
10
6
5
5
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
228
114
93
27
10
8
7
5
5
4
3
3
2
2
1
1
1
1
1
1
1
Host
Mouse
179
49
22
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PARK7 antibody is un-conjugated
15
11
7
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
218
114
76
55
49
39
22
16
14
8
6
6
3
3
1
1
Options
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Immunogen Recombinant human GST-DJ1 (1-189 aa) purified from E. coli
Clone 1B11
Isotype IgG1
Specificity This antibody detects Human Parkinson Disease Protein 7 (Park7/DJ-1). Other species not tested.
Purification Protein-G affinity chromatography
Alternative Name DJ-1 / PARK7 (PARK7 Antibody Abstract)
Background Park7/DJ-1, which is a small 189 amino acid protein, is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the Park7/DJ-1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (Park7).Synonyms: Oncogene DJ1, Parkinson disease protein 7
UniProt Q99497
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
Application Notes The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended dilution for Western blot is 1:500 approx. 1:2,000 (starting dilution is 1:1,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate-Buffered Saline, pH 7.4, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Can be stored at 2-8 °C for up to one month, but store at -20 °C for long term storage. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Junn, Taniguchi, Jeong, Zhao, Ichijo, Mouradian: "Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 27, pp. 9691-6, 2005 (PubMed).

Meulener, Graves, Sampathu, Armstrong-Gold, Bonini, Giasson: "DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein." in: Journal of neurochemistry, Vol. 93, Issue 6, pp. 1524-32, 2005 (PubMed).

Zhou, Freed: "DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity." in: The Journal of biological chemistry, Vol. 280, Issue 52, pp. 43150-8, 2005 (PubMed).

Bonifati, Rizzu, van Baren, Schaap, Breedveld, Krieger, Dekker, Squitieri, Ibanez, Joosse, van Dongen, Vanacore, van Swieten, Brice, Meco, van Duijn, Oostra, Heutink: "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism." in: Science (New York, N.Y.), Vol. 299, Issue 5604, pp. 256-9, 2003 (PubMed).