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Parkinson Protein 7 (PARK7) (AA 1-189), (N-Term) antibody

Details for Product No. ABIN121180, Supplier: Log in to see
Antigen
  • dj1
  • zgc:103725
  • DJ-1
  • Dj1
  • DJ1
  • CAP1
  • SP22
Epitope
AA 1-189, N-Term
34
31
13
12
10
9
6
4
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
196
78
67
9
7
6
5
4
4
3
3
2
2
1
1
1
1
1
1
Host
Mouse
168
31
19
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
12
9
6
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
173
108
65
41
33
20
13
11
7
6
6
1
Supplier
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Immunogen Recombinant human GST-DJ1 (1-189 aa) purified from E. coli
Clone 1B11
Isotype IgG1
Specificity This antibody detects Human Parkinson Disease Protein 7 (Park7/DJ-1). Other species not tested.
Purification Protein-G affinity chromatography
Alternative Name DJ-1 / PARK7 (PARK7 Antibody Abstract)
Background Park7/DJ-1, which is a small 189 amino acid protein, is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the Park7/DJ-1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (Park7).Synonyms: Oncogene DJ1, Parkinson disease protein 7
UniProt Q99497
Application Notes The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended dilution for Western blot is 1:500 approx. 1:2,000 (starting dilution is 1:1,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate-Buffered Saline, pH 7.4, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Can be stored at 2-8 °C for up to one month, but store at -20 °C for long term storage. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Zhou, Freed: "DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity." in: The Journal of biological chemistry, Vol. 280, Issue 52, pp. 43150-8, 2005 (PubMed).

Junn, Taniguchi, Jeong et al.: "Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 27, pp. 9691-6, 2005 (PubMed).

Meulener, Graves, Sampathu et al.: "DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein." in: Journal of neurochemistry, Vol. 93, Issue 6, pp. 1524-32, 2005 (PubMed).

Bonifati, Rizzu, van Baren et al.: "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism." in: Science (New York, N.Y.), Vol. 299, Issue 5604, pp. 256-9, 2003 (PubMed).