Calcitonin Receptor antibody

Catalog No. ABIN121621

Product Details anti-Calcitonin Receptor Antibody

Target: Calcitonin Receptor (CALCR)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calcitonin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: SP1338P reacts with the Calcitonin Receptor. It recognises an epitope within the cytoplasmic domain that is common to both C1a and C1b Rat isoforms.

Cross-Reactivity (Details): Species reactivity (tested):Rat. Cross reacts with Mouse and Human.

Purification: Affinity Chromatography on Protein A.

Immunogen: Synthetic peptide derived from sequence of rat calcitonin receptor

Application Details

Application Notes: Immunohistochemistry on paraffin embedded tissues (1:10 - 1:100): The use of 4 % paraformaldehyde fixation rather than formalin fixation is recommended. Does not require protein digestion pre-treatment nor antigen retrieval using heat prior to staining of paraffin embedded sections. Suitable positive control: Kidney, cultered osteoclasts. A sensitive detection system is also recommended, e.g. a catalysed signal amplification system). ELISA (1:10,000). Western blot using reducing conditions.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Expiry Date: 12 months

References for anti-Calcitonin Receptor antibody (ABIN121621)

Segovia-Silvestre, Bonnefond, Sondergaard, Christensen, Karsdal, Bay-Jensen: "Identification of the calcitonin receptor in osteoarthritic chondrocytes." in: BMC research notes, Vol. 4, pp. 407, (2011) (PubMed).

Target Details for Calcitonin Receptor

Target: Calcitonin Receptor (CALCR)

Alternative Name: Calcitonin Receptor (CALCR Products)

Synonyms: CALCR antibody, si:ch211-77k19.2 antibody, calcr antibody, CRT antibody, CT-R antibody, CTR antibody, CTR1 antibody, Clr antibody, Ct-R antibody, calcitonin receptor antibody, CALCR antibody, calcr antibody, Calcr antibody

Background: Calcitonin Receptor is a seven transmembrane domain cell surface protein which is coupled to G protein messenger systems. Calcitonin receptor is expressed in kidney, central and peripheral nervous systems and in osteoclasts. It is also expressed in a number of tissues during the development of the embyro and may be important in foetal morphogenesis.Synonyms: CALCR, CT-R, CTR

Gene ID: 116506

UniProt: P32214

Pathways: cAMP Metabolic Process