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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Caspase 1, Apoptosis-Related Cysteine Peptidase (Interleukin 1, Beta, Convertase) (CASP1) (C-Term) antibody
|Synonyms||ICE, P45, IL1BC, Il1bc, Ice, DCP-1, DCP1, l(2)01862, l(2)02132, DmelCG5370, CG5370, CASP1, LOC100033888|
Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|4 references available|
|Quantity||0.1 mg (1.0 mg/ml) (Variants)|
|Price||616.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 6 to 8 Business Days|
|Immunogen||A 16 amino acid peptide located near human Caspase-1 carboxy terminus|
|Description||Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to C. elegans cell death gene (ced-3). Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. This regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases. Alternate Names: CASP1, ICE, p45, IL-1BC, IL1BC, IL1BCE, Caspase 1, Caspase1, CASP 1, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme.|
|Application Notes||Western Blot: 0.5ug - 1.0ug/ml. Immunohistochemistry on paraffin sections: 0.5ug - 1.0ug/ml, This product does not require protein digestion pre-treatment of paraffin embedded sections e.g. trypsin or pronase prior to staining. Recommended Positive Control: Human heart tissue. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.|
|Buffer||PBS containing 0.02% Sodium Azide|
|Storage||Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.|
|Restrictions||For Research Use only|
Kostura, Tocci, Limjuco et al.: "Identification of a monocyte specific pre-interleukin 1 beta convertase activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 14, pp. 5227-31, 1989 (PubMed).
Miura, Zhu, Rotello et al.: "Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3." in: Cell, Vol. 75, Issue 4, pp. 653-60, 1993 (PubMed).
Ghayur, Banerjee, Hugunin et al.: "Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production." in: Nature, Vol. 386, Issue 6625, pp. 619-23, 1997 (PubMed).
Fantuzzi, Puren, Harding et al.: "Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice." in: Blood, Vol. 91, Issue 6, pp. 2118-25, 1998 (PubMed).