CALCRL antibody (N-Term)
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- Target See all CALCRL Antibodies
- CALCRL (Calcitonin Receptor-Like (CALCRL))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CALCRL antibody is un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- Reacts with Calcitonin Receptor-Like Receptor (Family: GPCR, subfamily: Adrenomedullin)
- Cross-Reactivity (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Immunoaffinity Chromatography.
- Immunogen
- Synthetic peptide - KLH conjugated
- Top Product
- Discover our top product CALCRL Primary Antibody
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- Application Notes
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Immunohistochemistry with formalin fixed paraffin embedded tissues: 16 μg/mL. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.09 % Sodium Azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
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Store the antibody undiluted at 2-8 °C for one month or(in aliquots) at -20 °C to -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - Expiry Date
- 12 months
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- Target
- CALCRL (Calcitonin Receptor-Like (CALCRL))
- Alternative Name
- CGRP Type 1 Receptor / CRLR (CALCRL Products)
- Synonyms
- CALCRL antibody, CGRPR antibody, CRLR antibody, AV071593 antibody, CLR antibody, Crlr antibody, RATCRLR antibody, RNCLR antibody, calcitonin receptor like receptor antibody, calcitonin receptor-like antibody, calcitonin receptor like receptor L homeolog antibody, CALCRL antibody, LOC100168906 antibody, calcrl antibody, Calcrl antibody, calcrl.L antibody
- Background
- Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.Synonyms: CALCRL, CGRPR, Calcitonin gene-related peptide type 1 receptor, Calcitonin receptor-like receptor
- Gene ID
- 10203
- UniProt
- Q16602
- Pathways
- cAMP Metabolic Process
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