Lamin A/C antibody

Catalog No. ABIN126713

The Mouse Monoclonal anti-Lamin A/C antibody is suitable to detect Lamin A/C in samples from Human, Cow, Xenopus laevis and Fish. It has been validated for WB and IF.

Quick Overview for Lamin A/C antibody (ABIN126713)

Target: Lamin A/C (LMNA)

Reactivity: Human, Cow, Xenopus laevis, Fish

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: X167

Product Details anti-Lamin A/C Antibody

Specificity: The monoclonal antibody decorates the karyoskeleton, i.e. the intermediate filament equivalent of the nucleus. Reacts with Lamin isotypes of Mr 60-75 kDa.

Cross-Reactivity (Details): Species reactivity (tested):Xenopus laevis (LA, LII) Bovine (LA, B1, B2, C)Mouse (n.d.) Rat (-) Human (LA, C) Trout (LA, LII,(LI))Rat kangaroo (-).

Purification: Affinity Chromatography on Protein A.

Immunogen: Nuclear pore complex-lamina fraction of Xenopus laevis (XLKE-A6 cells)

Isotype: IgG1

Application Details

Application Notes: Immunoblotting (Western). Immunofluorescence Microscopy: (1/10, Incubate 1h at RT).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 1 mL distilled water.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Do not freeze working dilutions

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin-A/C (LMNA)

Gene ID: 4000

NCBI Accession: NP_005563

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus